205494
二丁基二氯化锡
96%
别名:
二丁基二氯锡
应用
- 二丁基锡化合物对PPARγ/RXRα活性的影响：研究包括二氯化二丁基锡在内的各种二丁基锡化合物对哺乳动物细胞脂肪生成和炎症的影响，强调其对PPARγ/RXRα通路的影响（Milton et al., 2017）。
警示用语：
Danger
危险分类
Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Muta. 2 - Repr. 1B - Skin Corr. 1B - Skin Sens. 1 - STOT RE 1 Oral - STOT SE 1 Oral
靶器官
thymus
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
235.4 °F - closed cup
闪点(°C)
113 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
危险化学品
Fei Jiang et al.
Pancreas, 40(7), 1091-1096 (2011-09-20)
The α-tocopherol and tocotrienol-rich fraction (TRF) are considered effective antioxidants. This study aimed to compare the antioxidative and antifibrotic effects of α-tocopherol and TFR in dibutylin dichloride (DBTC)-induced chronic pancreatitis (CP) rats. Oral administration of α-tocopherol and TFR (both 800
Brit Fitzner et al.
Digestive diseases and sciences, 54(2), 309-320 (2008-07-10)
Pancreatic stellate cells (PSC) play a key role in pancreatic fibrosis. Activation of PSC occurs in response to pro-fibrogenic stimuli and is maintained by autocrine loops of mediators, such as endothelin (ET)-1. Here, we have evaluated effects of the dual
Makoto Ema et al.
Environmental toxicology, 22(1), 44-52 (2007-02-14)
In this study, we examined the adverse effects of dibutyltin on initiation and maintenance of pregnancy after maternal administration during early pregnancy in mice. Following successful mating, female ICR mice were given dibutyltin dichloride (DBTCl) at 0, 7.6, 15.2, or
H F Zhao et al.
Gut, 54(12), 1759-1767 (2005-11-15)
Monocyte chemoattractant protein 1 (MCP-1) is a member of the C-C chemokine family and exerts strong chemoattractant activity in monocytes, macrophages, and lymphocytes. Rat pancreatic fibrosis induced by dibutyltin dichloride (DBTC) is considered to be an appropriate chronic pancreatitis model
Atsushi Masamune et al.
American journal of physiology. Gastrointestinal and liver physiology, 294(1), G99-G108 (2007-10-27)
Activated pancreatic stellate cells (PSCs) play an important role in pancreatic fibrosis and inflammation, where oxidative stress is implicated in the pathogenesis. NADPH oxidase might be a source of reactive oxygen species (ROS) in the injured pancreas. This study aimed
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