209252
1-氯-3,5-二甲氧基苯
97%
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关于此项目
线性分子式:
ClC6H3(OCH3)2
化学文摘社编号:
分子量:
172.61
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
230-330-2
MDL number:
Assay:
97%
产品名称
1-氯-3,5-二甲氧基苯, 97%
InChI key
WQHNWJBSROXROL-UHFFFAOYSA-N
InChI
1S/C8H9ClO2/c1-10-7-3-6(9)4-8(5-7)11-2/h3-5H,1-2H3
SMILES string
COc1cc(Cl)cc(OC)c1
assay
97%
mp
34-36 °C (lit.)
functional group
chloro
Application
5-Chloro-1,3-dimethoxybenzene was used in the regioselective synthesis of TMC-264, tricyclic structure having chloro-1H-dibenzo[b,d]pyran-4,6-dione skeleton.
General description
5-Chloro-1,3-dimethoxybenzene participates in Suzuki-Miyaura cross-coupling reactions of aryl- and heteroaryl chlorides with potassium cyclobutyltrifluoroborate.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
233.6 °F - closed cup
flash_point_c
112 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
The first total synthesis and structural determination of TMC-264.
Tatsuta K, et al.
Tetrahedron Letters, 49(25), 4036-4039 (2008)
Gary A Molander et al.
The Journal of organic chemistry, 73(19), 7481-7485 (2008-09-02)
Suitable conditions were found for the Suzuki-Miyaura cross-coupling reaction of potassium cyclopropyl- and cyclobutyltrifluoroborates with aryl chlorides. Both of these secondary alkyl trifluoroborates coupled in moderate to excellent yield with electron-rich, electron-poor, and hindered aryl chlorides to give a variety
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