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线性分子式:
Cl2C3H2(CH3)CO2H
化学文摘社编号:
分子量:
169.01
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
215-901-6
Beilstein/REAXYS Number:
1937304
MDL number:
产品名称
2,2-二氯-1-甲基环丙烷羧酸, 98%
InChI key
BIUUWIKPBYWKEQ-UHFFFAOYSA-N
InChI
1S/C5H6Cl2O2/c1-4(3(8)9)2-5(4,6)7/h2H2,1H3,(H,8,9)
SMILES string
CC1(CC1(Cl)Cl)C(O)=O
assay
98%
form
solid
bp
85 °C/8 mmHg (lit.)
mp
60-65 °C (lit.)
functional group
carboxylic acid
chloro
Quality Level
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Application
2,2-Dichloro-1-methyl-cyclopropanecarboxylic acid was used in solid phase synthesis of α-hydroxy esters, inhibitors of amyloid-β production.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Owen B Wallace et al.
Bioorganic & medicinal chemistry letters, 13(6), 1203-1206 (2003-03-20)
Inhibitors of amyloid-beta (Abeta) protein production have been widely pursued as a potential treatment for Alzheimer's disease. Following the identification of a 5 microM screening hit, SAR was initiated using solid-phase synthetic techniques. Two series of alpha-hydroxy esters and ketones
Dmitriy Ovcharenko et al.
Cancer biology & therapy, 20(9), 1281-1289 (2019-06-27)
Dichloroacetate (DCA) is an inhibitor of pyruvate dehydrogenase kinase (PDK) that has been shown to reverse the Warburg effect and cause tumor cell death. Clinical research into the anti-cancer activity of DCA revealed high dosage requirements and reports of toxicity.
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