210218
3-二甲氨基-1,2-丙二醇
98%
别名:
(±)-3-(二甲氨基)-1,2-丙二醇, 1,2-二羟基-3-（二甲氨基）丙烷, 甲氧苄啶
质量水平
方案
98%
折射率
n20/D 1.4609 (lit.)
沸点
216-217 °C (lit.)
密度
1.004 g/mL at 25 °C (lit.)
官能团
amine
hydroxyl
SMILES字符串
CN(C)CC(O)CO
InChI
1S/C5H13NO2/c1-6(2)3-5(8)4-7/h5,7-8H,3-4H2,1-2H3
InChI key
QCMHUGYTOGXZIW-UHFFFAOYSA-N
应用
3-二甲胺基-1,2-丙二醇可用于制备：
- 合成阳离子脂质，N-[1-(2,3-二油氧基)丙基-N,N,N-三甲基氯化铵（DOTMA），用于DNA转染方案
- 茚满衍生的双噁唑啉
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1 - Skin Corr. 1B
储存分类代码
8A - Combustible corrosive hazardous materials
WGK
WGK 3
闪点(°F)
221.0 °F - closed cup
闪点(°C)
105 °C - closed cup
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
An efficient synthesis of indane-derived bis (oxazoline) and its application to hetero Diels-Alder reactions on polymer support.
Kurosu M, et al.
Tetrahedron Letters, 45(1), 145-148 (2004)
P L Felgner et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(21), 7413-7417 (1987-11-01)
A DNA-transfection protocol has been developed that makes use of a synthetic cationic lipid, N-[1-(2,3-dioleyloxy)propyl]-N,N,N-trimethylammonium chloride (DOTMA). Small unilamellar liposomes containing DOTMA interact spontaneously with DNA to form lipid-DNA complexes with 100% entrapment of the DNA, DOTMA facilitates fusion of
Shuo Fang et al.
International journal of pharmaceutics, 493(1-2), 460-465 (2015-08-11)
A novel dual drug-tailed betaine conjugate amphiphile has been firstly synthesized in which the polar headgroup is derived from glycine betaine and the hydrophobic tails are chlorambucil molecules. The newly prepared conjugate undergoes self-assembly to form stable liposome-like nanocapsules as
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