产品名称
4-氯苯甲酸甲酯, 99%
InChI key
LXNFVVDCCWUUKC-UHFFFAOYSA-N
InChI
1S/C8H7ClO2/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5H,1H3
SMILES string
COC(=O)c1ccc(Cl)cc1
assay
99%
form
solid
mp
42-44 °C (lit.)
functional group
chloro
ester
Application
使用4-氯苯甲酸甲酯，通过GC-MS方法定量测定氯苯氧异丁酸（CPIB）和水杨酸（氯贝特和阿司匹林的代谢产物）。
General description
4-氯苯甲酸甲酯与 KF 和聚甲基氢硅氧烷（PMHS）进行室温 Pd 介导的加氢脱卤反应，生成苯甲酸甲酯。在双卡宾钯络合物催化剂存在下，它与苯硼酸发生 Suzuki-Miyaura 偶联反应，生成 (4-苯基)-苯甲酸甲酯。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
224.6 °F - closed cup
flash_point_c
107.00 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
On the efficiency of two-coordinate palladium (0)N-heterocyclic carbene complexes in amination and Suzuki-Miyaura reactions of aryl chlorides.
Arentsen K, et al.
Tetrahedron, 61(41), 9710-9715 (2005)
Drugs and drug metabolites as environmental contaminants: chlorophenoxyisobutyrate and salicyclic acid in sewage water effluent.
C Hignite et al.
Life sciences, 20(2), 337-341 (1977-01-15)
Room temperature dehalogenation of chloroarenes by polymethylhydrosiloxane (PMHS) under palladium catalysis.
Rahaim Jr, et al.
Tetrahedron Letters, 43(49), 8823-8826 (2002)
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