222569
甲吡唑
99%
别名:
4-甲基吡唑
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关于此项目
经验公式（希尔记法）:
C4H6N2
化学文摘社编号:
分子量:
82.10
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
231-445-0
Beilstein/REAXYS Number:
105204
MDL number:
Assay:
99%
InChI key
RIKMMFOAQPJVMX-UHFFFAOYSA-N
InChI
1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
SMILES string
Cc1cn[nH]c1
assay
99%
Gene Information
human ... ADH1A(124), ADH1B(125), ADH1C(126)
bp
99-100 °C/6 mmHg (lit.)
solubility
alcohol: soluble(lit.), water: soluble(lit.)
density
0.993 g/mL at 25 °C (lit.)
General description
4-甲基吡唑抑制CYP2E1活性。它也可用作醇脱氢酶抑制剂。
Application
甲吡唑（4-甲基吡唑）可用作：
- 使用铜催化剂通过N-芳基化与溴苯反应来制备4-甲基-1-苯基-1H-吡唑的反应物。
- 通过硝化合成4-甲基-3（5）-硝基吡唑的起始物料。
- 4-甲基吡唑镓（III）配合物制备中的配体，作为潜在的抗肿瘤和抗病毒剂。
甲醇和乙二醇中毒的有效解毒剂。
Biochem/physiol Actions
醇脱氢酶抑制剂
醇脱氢酶抑制剂。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
204.8 °F - closed cup
flash_point_c
96 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Amanda M Barkley-Levenson et al.
Brain sciences, 11(1) (2021-01-23)
Central nervous system (CNS) hyperexcitability is a clinically significant feature of acute ethanol withdrawal. There is evidence for a genetic contribution to withdrawal severity, but specific genetic risk factors have not been identified. The gene glyoxalase 1 (Glo1) has been
Samjhana Thapaliya et al.
Autophagy, 10(4), 677-690 (2014-02-05)
Patients with alcoholic cirrhosis and hepatitis have severe muscle loss. Since ethanol impairs skeletal muscle protein synthesis but does not increase ubiquitin proteasome-mediated proteolysis, we investigated whether alcohol-induced autophagy contributes to muscle loss. Autophagy induction was studied in: A) Human
Marisa Battistella
The Annals of pharmacotherapy, 36(6), 1085-1089 (2002-05-23)
To assess the use of fomepizole in the treatment of ethylene glycol poisoning in the absence of hemodialysis. A MEDLINE search (1966-May 2001) of English-language literature pertaining to the use of fomepizole in ethylene glycol poisoning was performed. Key search
Jafar Shahraki et al.
Iranian journal of pharmaceutical research : IJPR, 12(4), 829-844 (2014-02-14)
In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes
Synthesis and characterization of potential antitumour and antiviral gallium (III) complexes of N-heterocycles
Kratz F, et al.
Polyhedron, 11(4), 487-498 (1992)
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