方案
99%
折射率
n20/D 1.495 (lit.)
沸点
99-100 °C/6 mmHg (lit.)
溶解性
alcohol: soluble(lit.)
water: soluble(lit.)
密度
0.993 g/mL at 25 °C (lit.)
SMILES字符串
Cc1cn[nH]c1
InChI
1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
InChI key
RIKMMFOAQPJVMX-UHFFFAOYSA-N
基因信息
human ... ADH1A(124), ADH1B(125), ADH1C(126)
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一般描述
4-甲基吡唑抑制CYP2E1活性。它也可用作醇脱氢酶抑制剂。
应用
甲吡唑（4-甲基吡唑）可用作：
- 使用铜催化剂通过N-芳基化与溴苯反应来制备4-甲基-1-苯基-1H-吡唑的反应物。
- 通过硝化合成4-甲基-3（5）-硝基吡唑的起始物料。
- 4-甲基吡唑镓（III）配合物制备中的配体，作为潜在的抗肿瘤和抗病毒剂。
甲醇和乙二醇中毒的有效解毒剂。
生化/生理作用
醇脱氢酶抑制剂
醇脱氢酶抑制剂。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
204.8 °F - closed cup
闪点(°C)
96 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Amanda M Barkley-Levenson et al.
Brain sciences, 11(1) (2021-01-23)
Central nervous system (CNS) hyperexcitability is a clinically significant feature of acute ethanol withdrawal. There is evidence for a genetic contribution to withdrawal severity, but specific genetic risk factors have not been identified. The gene glyoxalase 1 (Glo1) has been
Samjhana Thapaliya et al.
Autophagy, 10(4), 677-690 (2014-02-05)
Patients with alcoholic cirrhosis and hepatitis have severe muscle loss. Since ethanol impairs skeletal muscle protein synthesis but does not increase ubiquitin proteasome-mediated proteolysis, we investigated whether alcohol-induced autophagy contributes to muscle loss. Autophagy induction was studied in: A) Human
J Samuelson et al.
Archives of medical research, 23(2), 31-33 (1992-01-01)
Ethanol is the major metabolic product of glucose fermentation by the protozoan parasite E. histolytica under the anaerobic conditions found in the lumen of the colon. With the goal of finding new targets for anti-amebic drugs, the E. histolytica NADP(+)-dependent
Marisa Battistella
The Annals of pharmacotherapy, 36(6), 1085-1089 (2002-05-23)
To assess the use of fomepizole in the treatment of ethylene glycol poisoning in the absence of hemodialysis. A MEDLINE search (1966-May 2001) of English-language literature pertaining to the use of fomepizole in ethylene glycol poisoning was performed. Key search
Jafar Shahraki et al.
Iranian journal of pharmaceutical research : IJPR, 12(4), 829-844 (2014-02-14)
In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes
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