222569
甲吡唑
99%
别名:
4-甲基吡唑
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关于此项目
经验公式（希尔记法）:
C4H6N2
化学文摘社编号:
分子量:
82.10
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
231-445-0
Beilstein/REAXYS Number:
105204
MDL number:
产品名称
甲吡唑, 99%
InChI key
RIKMMFOAQPJVMX-UHFFFAOYSA-N
InChI
1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
SMILES string
Cc1cn[nH]c1
assay
99%
refractive index
n20/D 1.495 (lit.)
bp
99-100 °C/6 mmHg (lit.)
solubility
alcohol: soluble(lit.)
water: soluble(lit.)
density
0.993 g/mL at 25 °C (lit.)
Gene Information
human ... ADH1A(124), ADH1B(125), ADH1C(126)
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Application
甲吡唑（4-甲基吡唑）可用作：
- 使用铜催化剂通过N-芳基化与溴苯反应来制备4-甲基-1-苯基-1H-吡唑的反应物。
- 通过硝化合成4-甲基-3（5）-硝基吡唑的起始物料。
- 4-甲基吡唑镓（III）配合物制备中的配体，作为潜在的抗肿瘤和抗病毒剂。
甲醇和乙二醇中毒的有效解毒剂。
Biochem/physiol Actions
醇脱氢酶抑制剂
醇脱氢酶抑制剂。
General description
4-甲基吡唑抑制CYP2E1活性。它也可用作醇脱氢酶抑制剂。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
204.8 °F - closed cup
flash_point_c
96 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Ethanol is the major metabolic product of glucose fermentation by the protozoan parasite E. histolytica under the anaerobic conditions found in the lumen of the colon. With the goal of finding new targets for anti-amebic drugs, the E. histolytica NADP(+)-dependent
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Patients with alcoholic cirrhosis and hepatitis have severe muscle loss. Since ethanol impairs skeletal muscle protein synthesis but does not increase ubiquitin proteasome-mediated proteolysis, we investigated whether alcohol-induced autophagy contributes to muscle loss. Autophagy induction was studied in: A) Human
Mild Conditions for Copper-Catalysed N-Arylation of Pyrazoles
Cristau H-J, et al.
European Journal of Organic Chemistry, 2004(4), 695-709 (2004)
Synthesis and characterization of potential antitumour and antiviral gallium (III) complexes of N-heterocycles
Kratz F, et al.
Polyhedron, 11(4), 487-498 (1992)
Nitropyrazoles 17. Synthesis of 1-(3, 5-dinitrophenyl)-4-methyl-3, 5-dinitropyrazole and the study of its chemical transformations
Zaitsev AA, et al.
Russian Chemical Bulletin, 58(10), 2122-2128 (2009)
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