Merck
CN
所有图片(1)

文件

224952

Sigma-Aldrich

1-胡椒基哌嗪

97%

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经验公式（希尔记法）:
C12H16N2O2
CAS号:
32231-06-4
分子量:
220.27
EC 号:
250-968-5
MDL编号:
MFCD00005834
PubChem化学物质编号:
24853467
NACRES:
NA.22

质量水平

100

检测方案

97%

bp

147-149 °C/2 mmHg (lit.)

mp

36-40 °C (lit.)

SMILES string

C1CN(CCN1)Cc2ccc3OCOc3c2

InChI

1S/C12H16N2O2/c1-2-11-12(16-9-15-11)7-10(1)8-14-5-3-13-4-6-14/h1-2,7,13H,3-6,8-9H2

InChI key

NBOOZXVYXHATOW-UHFFFAOYSA-N

相关类别

一般描述

The effect of 1-piperonylpiperazine on 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity was studied.

应用

1-Piperonylpiperazine was used in the synthesis of acetyl-caffeic acid-1-piperonylpiperazine (HBU-47).

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

235.4 °F - closed cup

闪点(°C)

113 °C - closed cup

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Seon-Young Park et al.
International immunopharmacology, 19(1), 60-65 (2013-12-24)
In the present study, we synthesized a new hybrid compound by coupling caffeic acid and 1-piperonylpiperazine. The synthetic compound, acetyl-caffeic acid-1-piperonylpiperazine (HBU-47), showed potent anti-inflammatory effects inhibiting lipopolysaccharide (LPS)-induced production of nitric oxide (NO) in RAW264.7 macrophage cells. HBU-47 inhibited
Lilian H J Richter et al.
Journal of pharmaceutical and biomedical analysis, 143, 32-42 (2017-06-12)
Metabolism studies play an important role in clinical and forensic toxicology. Because of potential species differences in metabolism, human samples are best suitable for elucidating metabolism. However, in the case of new psychoactive substances (NPS), human samples of controlled studies
K Hashimoto et al.
European journal of pharmacology, 228(2-3), 171-174 (1992-09-01)
The effects of 1-piperonylpiperazine and N,alpha-dimethylpiperonylamine, which are weak inhibitors for [3H]5-hydroxytryptamine (5-HT) uptake, on 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity were examined. The reductions of serotonergic parameters in the rat cerebral cortex produced by multiple administration of MDMA (10 mg/kg) were attenuated
K Hashimoto et al.
Brain research, 590(1-2), 341-344 (1992-09-11)
The neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA) in rat brain was attenuated significantly by coadministration of several benzylpiperazines (p-nitrobenzylpiperazine, p-chlorobenzylpiperazine and 1-piperonylpiperazine), which were weak inhibitors for [3H]6-nitroquipazine binding to the 5-hydroxytryptamine (5-HT) transporter in rat brain. These results suggest that these
Marcelo Dutra Arbo et al.
Archives of toxicology, 90(12), 3045-3060 (2016-01-29)
The piperazine derivatives most frequently consumed for recreational purposes are 1-benzylpiperazine, 1-(3,4-methylenedioxybenzyl) piperazine, 1-(3-trifluoromethylphenyl) piperazine and 1-(4-methoxyphenyl) piperazine. Generally, they are consumed as capsules, tablets or pills but also in powder or liquid forms. Currently, the precise mechanism by which

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