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22600

奎尼丁

Name: 奎尼丁
Brand: ALDRICH

crystallized, ≥98.0% (dried material, NT)

别名:

β-Quinidine, (+)-Quinidine, (9S)-6′-Methoxycinchonan-9-ol, Chinidin

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₄N₂O₂

化学文摘社编号:

56-54-2

分子量:

324.42

UNSPSC Code:

12352103

NACRES:

NA.22

PubChem Substance ID:

57647992

EC Number:

200-279-0

Beilstein/REAXYS Number:

91866

MDL number:

MFCD00135581

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属性

Quality Level

100

assay

≥98.0% (dried material, NT)

form

solid

optical activity

[α]20/D +265±5°, c = 0.8% in ethanol (dry matter)

quality

crystallized

impurities

≤2% water, ~10% hydroquinidine (HPLC)

mp

168-172 °C (lit.)

functional group

hydroxyl

SMILES string

COc1ccc2nccc([C@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1

InChI

1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1

InChI key

LOUPRKONTZGTKE-LHHVKLHASA-N

Gene Information

human ... ABCB1(5243), CYP2D6(1565), CYP3A4(1576), KCNH1(3756), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
mouse ... Abcb1a(18671), Abcb1b(18669)
rat ... Cyp2d1(266684), Cyp2d2(25053), Cyp2d3(24303), Cyp2d4v1(171522)

说明

General description

Quinidine is an isomer of quinine.

Application

Quinidine may be used in the preparation of O-trimethylsilylquinidine by reacting trimethylsilyl chloride.

Biochem/physiol Actions

IA 类抗心律失常药；钾通道阻断剂。

Other Notes

手性催化剂，用于，例如，高度不对称 [2+2] 环加成反应

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pictograms

GHS06

signalword

Danger

hcodes

H301,H317

pcodes

P261 - P264 - P272 - P280 - P301 + P310 - P302 + P352

Hazard Classifications

Acute Tox. 3 Oral - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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分析证书(COA)

Lot/Batch Number

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实验方案

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

The Journal of Organic Chemistry, 50, 1977-1977 (1985)

P.E. Ketelaar et al.

Tetrahedron Letters, 26, 4665-4665 (1985)

Quinidine, a life-saving medication for Brugada syndrome, is inaccessible in many countries.

Sami Viskin et al.

Journal of the American College of Cardiology, 61(23), 2383-2387 (2013-04-16)

The aim of this study was to determine the availability of quinidine throughout the world. Quinidine is the only oral medication that is effective for preventing life-threatening ventricular arrhythmias due to Brugada syndrome and idiopathic ventricular fibrillation. However, because of

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全球贸易项目编号

货号	GTIN
22600-10G-F	04061838779939
22600-50G-F	04061838779946