231282
α-细辛脑
98%
别名:
反式-1,2,4-三甲氧基-5-(1-丙烯基)苯, 反式-1-丙烯基-2,4,5-三甲氧基苯
方案
98%
表单
powder
沸点
296 °C (lit.)
mp
57-61 °C (lit.)
SMILES字符串
COc1cc(OC)c(\C=C\C)cc1OC
InChI
1S/C12H16O3/c1-5-6-9-7-11(14-3)12(15-4)8-10(9)13-2/h5-8H,1-4H3/b6-5+
InChI key
RKFAZBXYICVSKP-AATRIKPKSA-N
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一般描述
α-Asarone is an effective component isolated from the chinese medicinal herb Acorus tatarinowii. It is clinically used as medication for treating epilepsy, cough, bronchitis and asthma. It exhibits neuroprotective, anti-oxidative, anticonvulsive and cognitive enhancing action.
应用
α-Asarone was used in the synthesis of series of α-asarone isomers and were investigated for their hypolipidemic and antiplatelet activities.
Jung-Won Shin et al.
Biomolecules & therapeutics, 22(1), 17-26 (2014-03-07)
α-Asarone exhibits a number of pharmacological actions including neuroprotective, anti-oxidative, anticonvulsive, and cognitive enhancing action. The present study investigated the effects of α-asarone on pro-inflammatory cytokines mRNA, microglial activation, and neuronal damage in the hippocampus and on learning and memory
J Poplawski et al.
Journal of medicinal chemistry, 43(20), 3671-3676 (2000-10-06)
A series of alpha-asarone isomers was synthesized and investigated for their hypolipidemic and antiplatelet activity. Considering the hypolipidemic activity in rats at a dose of 80 mg/kg/day, some isomers were more potent than clofibrate at 150 mg/kg. Compound 3 was
Ze-Jun Wang et al.
Frontiers in pharmacology, 5, 40-40 (2014-03-22)
Alpha (α)-asarone, a major effective component isolated from the Chinese medicinal herb Acorus tatarinowii, is clinically used as medication for treating epilepsy, cough, bronchitis, and asthma. In the present study, we demonstrated that α-asarone targets central nervous system GABAA receptor
Cheol Hyeong Park et al.
Archives of pharmacal research, 34(8), 1289-1296 (2011-09-13)
The purification of a MeOH extract from the rhizome of Acorus gramineus (Araceae) using column chromatography furnished two new stereoisomers of phenylpropanoid, acoraminol A (1) and acoraimol B (2). It also furnished 17 known phenolic compounds, β-asarone (3), asaraldehyde (4)
Chunjuan Ren et al.
Die Pharmazie, 66(11), 875-880 (2011-12-30)
Alpha-Asarone is clinically used as a commercial intravenous formulation (CA-AREs). However, Polysorbate 80, a solubilizing agent contained in the formulation has been reported to be toxic. To enhance the aqueous solubility of ARE and to reduce the toxicity of CA-AREs
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