23181
氯甲酸氯甲酯
≥98.0% (GC)
别名:
1-氯甲基氯甲酸酯, 氯甲基氯化碳, 氯甲氧羰基氯, 氯甲酸氯甲酯, 氯碳酸氯甲基酯
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关于此项目
线性分子式:
ClCOOCH2Cl
化学文摘社编号:
分子量:
128.94
MDL number:
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
244-793-3
Beilstein/REAXYS Number:
506426
Assay:
≥98.0% (GC)
Form:
liquid
InChI key
JYWJULGYGOLCGW-UHFFFAOYSA-N
InChI
1S/C2H2Cl2O2/c3-1-6-2(4)5/h1H2
SMILES string
ClCOC(Cl)=O
assay
≥98.0% (GC)
form
liquid
refractive index
n20/D 1.428
bp
107-108 °C (lit.)
density
1.450 g/mL at 20 °C
functional group
chloro
storage temp.
2-8°C
Quality Level
Application
氯甲酸氯甲基酯作为关键反应物用于合成：
- 双氯芬酸和氟芬那酸的新型氨基羰基氧甲酯
- 环孢菌素 A 的高水溶性单甲氧基聚乙二醇前体药物
- 3-乙酰氧基甲氧羰基-1-芳基-3-甲基三氮烯系列
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Skin Corr. 1B
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
203.0 °F - closed cup
flash_point_c
95 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
E Carvalho et al.
Bioorganic & medicinal chemistry, 8(7), 1719-1725 (2000-09-08)
A series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes 5 was synthesised by the sequential reaction of 1-aryl-3-methyltriazenes with (i) chloromethyl chloroformate, (ii) NaI in dry acetone, and (iii) either the silver carboxylate or the carboxylic acids in the presence of silver carbonate. The hydrolysis
Lina Ribeiro et al.
Archiv der Pharmazie, 340(1), 32-40 (2007-01-09)
Aminocarbonyloxymethyl ester prodrugs are known to undergo rearrangement in aqueous solutions to form the corresponding N-acylamine side product via an O-->N intramolecular acyl transfer from the carbamate conjugate base. Novel aminocarbonyloxymethyl esters of diclofenac and flufenamic acid containing amino acid
Hoon Cho et al.
Archives of pharmacal research, 27(6), 662-669 (2004-07-31)
The highly water-soluble monomethoxypoly(ethyleneglycol) (mPEG) prodrugs of cyclosporin A (CsA) were synthesized. These prodrugs were prepared by initially preparing intermediate in the form of carbonate at the 3'-positions of CsA with chloromethyl chloroformate, in the presence of a base to
Keivan Sadrerafi et al.
Drug design, development and therapy, 12, 987-995 (2018-05-08)
Our previous study indicated that carborane containing small-molecule 1-(hydroxymethyl)-7-(4'-(trans-3″-(3'″-pyridyl)acrylamido)butyl)-1,7-dicarbadodecaborane (hm-MC4-PPEA), was a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt). Nampt has been shown to be upregulated in most cancers and is a promising target for the treatment of many different types
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