233412
2-肟氰乙酸乙酯
97%, for peptide synthesis
别名:
异亚硝基氰基乙酸乙酯, 氰基(羟基亚氨基)乙酸乙酯, 氰基乙醛酸乙酯-2-肟, 肟基氰乙酸乙酯
产品名称
2-肟氰乙酸乙酯, 97%
质量水平
方案
97%
表单
solid
mp
130-132 °C (lit.)
应用
peptide synthesis
官能团
amine
ester
nitrile
oxime
SMILES字符串
CCOC(=O)C(=N\O)\C#N
InChI
1S/C5H6N2O3/c1-2-10-5(8)4(3-6)7-9/h9H,2H2,1H3/b7-4+
InChI key
LCFXLZAXGXOXAP-QPJJXVBHSA-N
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一般描述
2-肟氰乙酸乙酯是肽合成中所用苯并三唑和苯并三唑衍生物的潜在替代品。
2-肟氰乙酸乙酯也称Oxyma。它是酰胺和肽合成的更为高效绿色替代产品。
2-肟氰乙酸乙酯也称Oxyma。它是酰胺和肽合成的更为高效绿色替代产品。
应用
在成熟的肽合成方法中，2-肟氰乙酸乙酯被用作添加剂，帮助形成碳二亚胺介导的酰胺键。肽类合成级材料请见产品 851086。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Alvin W Hung et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(17), 6799-6804 (2011-04-13)
Fragment-based drug discovery (FBDD) has proven to be an effective means of producing high-quality chemical ligands as starting points for drug-discovery pursuits. The increasing number of clinical candidate drugs developed using FBDD approaches is a testament of the efficacy of
Doaa M Anwar et al.
Bioconjugate chemistry, 29(9), 3026-3041 (2018-08-16)
In this study, promising approaches of dual-targeted micelles and drug-polymer conjugation were combined to enable injection of poorly soluble anticancer drugs together with site-specific drug release. Ursodeoxycholic acid (UDCA) as a hepatoprotective agent was grafted to maltodextrin (MD) via carbodiimide
Miriam Reverter et al.
Metabolites, 10(6) (2020-06-04)
Understanding natural defense mechanisms against parasites can be a valuable tool for the development of innovative therapies. We have previously identified a butterflyfish species (Chaetodonlunulatus) that avoids gill monogenean parasites while living amongst closely related parasitized species. The metabolome and
Ranko Gacesa et al.
International journal of molecular sciences, 21(20) (2020-10-16)
Siderophores are iron-complexing compounds synthesized by bacteria and fungi. They are low molecular weight compounds (500-1500 Daltons) possessing high affinity for iron(III). Since 1970 a large number of siderophores have been characterized, the majority using hydroxamate or catecholate as functional
Hangyu Zhang et al.
Acta biomaterialia, 55, 183-193 (2017-04-04)
Self-assembling peptides programed by sequence design to form predefined nanostructures are useful for a variety of biomedical applications. However, assemblies of classic ionic self-complementary peptides are unstable in neutral pH, while charged peptide hydrogels have low mechanical strength. Here, we
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