234478
1-氯-3-碘丙烷
99%
别名:
Trimethylene chloroiodide
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关于此项目
线性分子式:
Cl(CH2)3I
化学文摘社编号:
分子量:
204.44
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
230-088-8
Beilstein/REAXYS Number:
1731115
MDL number:
Assay:
99%
Form:
liquid
产品名称
1-氯-3-碘丙烷, 99%
InChI key
SFOYQZYQTQDRIY-UHFFFAOYSA-N
InChI
1S/C3H6ClI/c4-2-1-3-5/h1-3H2
SMILES string
ClCCCI
vapor density
6.8 (vs air)
vapor pressure
2 mmHg ( 20 °C)
assay
99%
form
liquid
contains
copper as stabilizer
refractive index
n20/D 1.548 (lit.)
bp
170-172 °C (lit.)
density
1.904 g/mL at 25 °C (lit.)
functional group
chloro
iodo
Quality Level
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Application
1-氯-3-碘丙烷已被用于合成：
- N- [4- [5-（2,4-二氨基-6-氧代-1,6-二氢嘧啶-5-基）-2-（2,2,2-三氟乙酰基）戊基]苯甲酰基] -L-谷氨酸，一种甘氨酰胺核糖核苷酸转化酶（GAR Tfase）和氨基咪唑羧酰胺核糖核苷酸转化酶（AICAR Tfase）的抑制剂
- 有趣的″蛋白海绵″型分子喹[7,8-h]喹啉
General description
1-氯-3-碘丙烷可与N-亚磺酰亚胺进行不对称的α-烷基化反应，生成2-取代的N-叔丁烷亚磺酰基-5-氯戊酰胺。通过循环伏安法对含有碳四正丁基铵的二甲基甲酰胺中玻璃碳电极上的1-氯-3-碘丙烷电还原反应进行了研究。它也参与到在水中将烷基碘共轭加成到α,β-不饱和腈上。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
230.0 °F - closed cup
flash_point_c
110 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Synthesis of 1, 2, 3, 4-tetrahydroquinolines and 1, 2, 3, 4-tetrahydro-1, 6-naphthyridines by a directed lithiation reaction.
Reed JN, et al.
Tetrahedron Letters, 29(45), 5725-5728 (1988)
Electrochemical Reduction of 1, 3-Dihalopropanes at Carbon Cathodes in Dimethylformamide.
Pritts WA and Peters DG.
Journal of the Electrochemical Society, 141(4), 990-995 (1994)
Fraser F Fleming et al.
The Journal of organic chemistry, 72(18), 6961-6969 (2007-08-10)
A new silica-supported zinc-copper matrix reagent promotes the conjugate addition of alkyl iodides to cyclic and acyclic alkenenitriles in water. X-ray diffraction and electron microscopy techniques suggest that the active copper species generated from elemental zinc and copper(I) iodide is
Filip Colpaert et al.
The Journal of organic chemistry, 76(1), 234-244 (2010-12-02)
α-Alkylation of N-sulfinyl imidates with 1-chloro-3-iodopropane successfully led to 2-substituted N-tert-butanesulfinyl-5-chloropentanimidates in acceptable diastereomeric ratios (dr 67/33 to 72/28) and good yields (74-86%). Subsequent reduction with NaBH(4) led to the corresponding 2-substituted N-tert-butanesulfinyl-5-chloropentylamines, which could be cyclized to a range
Heng Cheng et al.
Bioorganic & medicinal chemistry, 13(10), 3593-3599 (2005-04-26)
The synthesis and evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid (2) as an inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase) are reported. The inhibitor 2 was prepared in a convergent synthesis involving C-alkylation of methyl 4-(4,4,4-trifluoro-3-dimethylhydrazonobutyl)benzoate
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