235199
7-甲氧基香豆素-4-乙酸
97%
别名:
7-甲氧基-2-氧代-2H-1-苯并吡喃-4-乙酸
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关于此项目
经验公式（希尔记法）:
C12H10O5
化学文摘社编号:
分子量:
234.20
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
产品名称
7-甲氧基香豆素-4-乙酸, 97%
InChI
1S/C12H10O5/c1-16-8-2-3-9-7(4-11(13)14)5-12(15)17-10(9)6-8/h2-3,5-6H,4H2,1H3,(H,13,14)
SMILES string
COc1ccc2C(CC(O)=O)=CC(=O)Oc2c1
InChI key
ZEKAXIFHLIITGV-UHFFFAOYSA-N
assay
97%
mp
193 °C (dec.) (lit.)
solubility
DMF: soluble 50 mg/mL, clear, colorless to yellow
functional group
carboxylic acid
ester
Quality Level
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Application
已使用7-甲氧基香豆素-4-乙酸：
- 作为荧光探针，制备两个新型LysB29选择性标记的人胰岛素荧光衍生物
- 在细胞穿膜肽转运蛋白10（tp10）的制备中
- 作为肽的荧光标记
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Tianshu Xiao et al.
Nature structural & molecular biology, 28(2), 202-209 (2021-01-13)
Effective intervention strategies are urgently needed to control the COVID-19 pandemic. Human angiotensin-converting enzyme 2 (ACE2) is a membrane-bound carboxypeptidase that forms a dimer and serves as the cellular receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 is
Alice Ciencialová et al.
Journal of peptide science : an official publication of the European Peptide Society, 10(7), 470-478 (2004-08-10)
The preparation and characterization of two novel LysB29 selectively labelled fluorescent derivatives of human insulin are described. Two probes were chosen: 4-chloro-7-nitrobenz-2-oxa-1,3-diazole (NBD) and 7-methoxycoumarin-4-acetic acid (MCA), which have a relatively small, compact structure and are able to react with
Lindsay E Yandek et al.
Biophysical journal, 92(7), 2434-2444 (2007-01-16)
The mechanism of the interaction between the cell-penetrating peptide transportan 10 (tp10) and phospholipid membranes was investigated. Tp10 induces graded release of the contents of phospholipid vesicles. The kinetics of peptide association with vesicles and peptide-induced dye efflux from the
Stereospecific synthesis ofl-2-amino-3-(7-methoxy-4-coumaryl) propionic acid, an alternative to tryptophan in quenched fluorescent substrates for peptidases.
Knight CG.
Lett. Pept. Sci., 5(1), 1-4 (1998)
Marzena Kurzawa-Akanbi et al.
Journal of neurochemistry, 123(2), 298-309 (2012-07-19)
Lewy body disease (LBD) development is enhanced by mutations in the GBA gene coding for glucocerebrosidase (GCase). The mechanism of this association is thought to involve an abnormal lysosomal system and we therefore sought to evaluate if lysosomal changes contribute
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