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Merck
CN

235199

Sigma-Aldrich

7-甲氧基香豆素-4-乙酸

97%

别名:

7-甲氧基-2-氧代-2H-1-苯并吡喃-4-乙酸

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关于此项目

经验公式(希尔记法):
C12H10O5
CAS Number:
分子量:
234.20
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
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质量水平

方案

97%

mp

193 °C (dec.) (lit.)

溶解性

DMF: soluble 50 mg/mL, clear, colorless to yellow

官能团

carboxylic acid
ester

SMILES字符串

COc1ccc2C(CC(O)=O)=CC(=O)Oc2c1

InChI

1S/C12H10O5/c1-16-8-2-3-9-7(4-11(13)14)5-12(15)17-10(9)6-8/h2-3,5-6H,4H2,1H3,(H,13,14)

InChI key

ZEKAXIFHLIITGV-UHFFFAOYSA-N

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应用

已使用7-甲氧基香豆素-4-乙酸:
  • 作为荧光探针,制备两个新型LysB29选择性标记的人胰岛素荧光衍生物
  • 在细胞穿膜肽转运蛋白10(tp10)的制备中
  • 作为肽的荧光标记

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Tianshu Xiao et al.
Nature structural & molecular biology, 28(2), 202-209 (2021-01-13)
Effective intervention strategies are urgently needed to control the COVID-19 pandemic. Human angiotensin-converting enzyme 2 (ACE2) is a membrane-bound carboxypeptidase that forms a dimer and serves as the cellular receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 is
Stereospecific synthesis ofl-2-amino-3-(7-methoxy-4-coumaryl) propionic acid, an alternative to tryptophan in quenched fluorescent substrates for peptidases.
Knight CG.
Lett. Pept. Sci., 5(1), 1-4 (1998)
Lindsay E Yandek et al.
Biophysical journal, 92(7), 2434-2444 (2007-01-16)
The mechanism of the interaction between the cell-penetrating peptide transportan 10 (tp10) and phospholipid membranes was investigated. Tp10 induces graded release of the contents of phospholipid vesicles. The kinetics of peptide association with vesicles and peptide-induced dye efflux from the
Marzena Kurzawa-Akanbi et al.
Journal of neurochemistry, 123(2), 298-309 (2012-07-19)
Lewy body disease (LBD) development is enhanced by mutations in the GBA gene coding for glucocerebrosidase (GCase). The mechanism of this association is thought to involve an abnormal lysosomal system and we therefore sought to evaluate if lysosomal changes contribute
Hisatsugu Koshimizu et al.
Molecular brain, 2, 27-27 (2009-08-14)
Proneurotrophins and mature neurotrophins elicit opposite effects via the p75 neurotrophin receptor (p75(NTR)) and Trk tyrosine kinase receptors, respectively; however the molecular roles of proneurotrophins in the CNS are not fully understood. Based on two rare single nucleotide polymorphisms (SNPs)

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