245305
(1R)-(-)-氯甲酸薄荷酯
optical purity ee: 99% (GLC)
别名:
(-)-氯甲酸薄荷酯
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关于此项目
经验公式（希尔记法）:
C11H19ClO2
化学文摘社编号:
分子量:
218.72
MDL number:
Beilstein/REAXYS Number:
2414686
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
产品名称
(1R)-(-)-氯甲酸薄荷酯, optical purity ee: 99% (GLC)
InChI
1S/C11H19ClO2/c1-7(2)9-5-4-8(3)6-10(9)14-11(12)13/h7-10H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
SMILES string
CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(Cl)=O
InChI key
KIUPCUCGVCGPPA-KXUCPTDWSA-N
vapor pressure
0.01 psi ( 20 °C)
form
liquid
optical activity
[α]20/D −83°, c = 1 in chloroform
optical purity
ee: 99% (GLC)
refractive index
n20/D 1.458 (lit.)
bp
108-109 °C/11 mmHg (lit.)
density
1.02 g/mL at 25 °C (lit.)
functional group
chloro
storage temp.
2-8°C
Application
1 R ）-(-)-薄荷基氯甲酸酯可用于制备 1- O -薄荷氧羰基 肌醇 -肌醇。
易于形成氯亚氨重碳酸盐，可在温和条件下不对称氯化硅基烯醇醚并且产量高。
用于通过 GC、HPLC 或结晶作用来拆分醇类和胺类的手性衍生试剂。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Skin Corr. 1B
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
158.0 °F - closed cup
flash_point_c
70 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Man-Jeong Paik et al.
Journal of chromatography. A, 1103(1), 177-181 (2005-12-20)
Solvent extractive two-phase menthoxycarbonyl (MnOC) derivatization was combined with trimethylsilyl (TMS) reaction for enantioseparation of beta-blockers by gas chromatography employing achiral DB-5 and DB-17 dual-columns of different polarity. beta-Blockers in alkaline solution were vortex-mixed with menthyl chloroformate present in dichloromethane
Journal of the Chemical Society. Chemical Communications, 470-470 (1987)
Saumen Hajra et al.
The Journal of organic chemistry, 72(13), 4872-4876 (2007-06-05)
New chiral N-chloroimidodicarbonates, which function as efficient chiral chlorinating agents, were designed and synthesized. Among these, C(2)-symmetric (1R,2S,5R)-(-)-menthyl-N-chloroimidodicarbonate 2a provided moderate to good enantioselectivity (up to 40%) for the chlorination of silyl enol ethers to afford alpha-chloroketones only in the
K H Kim et al.
Archives of pharmacal research, 22(6), 608-613 (2000-01-01)
Optimum conditions of chiral derivatization reaction of beta-blockers acebutolol, arotinolol, beta-xolol, bisoprolol, celiprolol, metoprolol and pindolol) with (-)-menthyl chloroformate were investigated for the resolution by HPLC. With more than 30 times molar excess of (-)-menthyl chloroformate chiral derivatization reactions were
F Li et al.
Journal of chromatography, 622(2), 187-195 (1993-12-22)
A simple and sensitive high-performance liquid chromatographic (HPLC) method using chiral derivatization was developed to screen and determine the enantiomers of moprolol and their metabolites in human urine. The recovery of (+)- and (-)-moprolol from urine was 70.8-81.1% at different
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