245305
(1R)-(-)-氯甲酸薄荷酯
optical purity ee: 99% (GLC)
别名:
(-)-氯甲酸薄荷酯
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关于此项目
经验公式（希尔记法）:
C11H19ClO2
化学文摘社编号:
分子量:
218.72
MDL number:
Beilstein/REAXYS Number:
2414686
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
Form:
liquid
InChI
1S/C11H19ClO2/c1-7(2)9-5-4-8(3)6-10(9)14-11(12)13/h7-10H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
SMILES string
CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(Cl)=O
InChI key
KIUPCUCGVCGPPA-KXUCPTDWSA-N
vapor pressure
0.01 psi ( 20 °C)
form
liquid
optical activity
[α]20/D −83°, c = 1 in chloroform
optical purity
ee: 99% (GLC)
refractive index
n20/D 1.458 (lit.)
bp
108-109 °C/11 mmHg (lit.)
density
1.02 g/mL at 25 °C (lit.)
functional group
chloro
storage temp.
2-8°C
Application
1 R ）-(-)-薄荷基氯甲酸酯可用于制备 1- O -薄荷氧羰基 肌醇 -肌醇。
易于形成氯亚氨重碳酸盐，可在温和条件下不对称氯化硅基烯醇醚并且产量高。
用于通过 GC、HPLC 或结晶作用来拆分醇类和胺类的手性衍生试剂。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Skin Corr. 1B
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
158.0 °F - closed cup
flash_point_c
70 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Stereospecific liquid chromatographic analysis of racemic adrenergic drugs utilizing precolumn derivatization with (-)-menthyl chloroformate.
R Mehvar
Journal of chromatography, 493(2), 402-408 (1989-09-01)
Ju-Il Sung et al.
Archives of pharmacal research, 33(9), 1301-1306 (2010-10-15)
Stereoisomers of nadolol were derivatized with S-(-)-menthyl chloroformate((-)-MCF) forming their diastereomers, RSR-nadolol-(-)-MCF, SRS-nadolol-(-)-MCF, RRS-nadolol-(-)-MCF and SSRnadolol-(-)-MCF. Diastereomeric mixture were then chromatographically resolved by preparative HPLC (JAIGEL-ODS-BP-L, 500 × 25 mm column) eluted with methanol-water (84:16, v/v) at flow rate 2.5
E B Christensen et al.
Journal of chromatography. B, Biomedical applications, 670(2), 243-249 (1995-08-18)
A fast high-performance liquid chromatographic (HPLC) assay was developed for determination of tocainide enantiomers in plasma. Subsequent to solid-phase extraction of tocainide from plasma, homochiral derivatization with (-)-menthyl chloroformate enabled separation of the enantiomers by a conventional reversed-phase HPLC system.
K H Kim et al.
Archives of pharmacal research, 22(6), 614-618 (2000-01-01)
A reversed-phase high-performance liquid chromatographic method was developed to determine the optical purity of metoprolol enantiomers. The enantiomers were converted to diastereomeric derivatives using (-)-menthyl chloroformate reagent. Separation of the enantiomers as diastereomers was achieved by reversed-phase HPLC within 30
N Domergue et al.
Analytical biochemistry, 214(2), 420-425 (1993-11-01)
Amino acids dissolved in aqueous methanol (or ethanol) and treated with optically active menthyl chloroformate were converted into N-menthyloxycarbonyl methyl (or ethyl) ester derivatives within a few minutes at room temperature. The obtained diastereomeric derivatives, with the exception of arginine
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