245305
(1R)-(-)-氯甲酸薄荷酯
optical purity ee: 99% (GLC)
别名:
(-)-氯甲酸薄荷酯
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关于此项目
经验公式（希尔记法）:
C11H19ClO2
CAS Number:
分子量:
218.72
Beilstein:
2414686
MDL编号:
UNSPSC代码:
12352101
PubChem化学物质编号:
NACRES:
NA.22
蒸汽压
0.01 psi ( 20 °C)
表单
liquid
旋光性
[α]20/D −83°, c = 1 in chloroform
光学纯度
ee: 99% (GLC)
折射率
n20/D 1.458 (lit.)
沸点
108-109 °C/11 mmHg (lit.)
密度
1.02 g/mL at 25 °C (lit.)
官能团
chloro
储存温度
2-8°C
SMILES字符串
CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(Cl)=O
InChI
1S/C11H19ClO2/c1-7(2)9-5-4-8(3)6-10(9)14-11(12)13/h7-10H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
InChI key
KIUPCUCGVCGPPA-KXUCPTDWSA-N
应用
1 R ）-(-)-薄荷基氯甲酸酯可用于制备 1- O -薄荷氧羰基 肌醇 -肌醇。
易于形成氯亚氨重碳酸盐，可在温和条件下不对称氯化硅基烯醇醚并且产量高。
用于通过 GC、HPLC 或结晶作用来拆分醇类和胺类的手性衍生试剂。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Inhalation - Skin Corr. 1B
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
158.0 °F - closed cup
闪点(°C)
70 °C - closed cup
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
E B Christensen et al.
Journal of chromatography. B, Biomedical applications, 670(2), 243-249 (1995-08-18)
A fast high-performance liquid chromatographic (HPLC) assay was developed for determination of tocainide enantiomers in plasma. Subsequent to solid-phase extraction of tocainide from plasma, homochiral derivatization with (-)-menthyl chloroformate enabled separation of the enantiomers by a conventional reversed-phase HPLC system.
Ju-Il Sung et al.
Archives of pharmacal research, 33(9), 1301-1306 (2010-10-15)
Stereoisomers of nadolol were derivatized with S-(-)-menthyl chloroformate((-)-MCF) forming their diastereomers, RSR-nadolol-(-)-MCF, SRS-nadolol-(-)-MCF, RRS-nadolol-(-)-MCF and SSRnadolol-(-)-MCF. Diastereomeric mixture were then chromatographically resolved by preparative HPLC (JAIGEL-ODS-BP-L, 500 × 25 mm column) eluted with methanol-water (84:16, v/v) at flow rate 2.5
K H Kim et al.
Archives of pharmacal research, 22(6), 614-618 (2000-01-01)
A reversed-phase high-performance liquid chromatographic method was developed to determine the optical purity of metoprolol enantiomers. The enantiomers were converted to diastereomeric derivatives using (-)-menthyl chloroformate reagent. Separation of the enantiomers as diastereomers was achieved by reversed-phase HPLC within 30
N Domergue et al.
Analytical biochemistry, 214(2), 420-425 (1993-11-01)
Amino acids dissolved in aqueous methanol (or ethanol) and treated with optically active menthyl chloroformate were converted into N-menthyloxycarbonyl methyl (or ethyl) ester derivatives within a few minutes at room temperature. The obtained diastereomeric derivatives, with the exception of arginine
Resolution of antihypertensive aryloxypropanolamine enantiomers by reversed-phase chromatography of (-)-menthyl chloroformate derivatives.
H F Schmitthenner et al.
Journal of chromatography, 487(1), 197-203 (1989-01-27)
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