245879
1-溴频哪酮
technical grade, ~90%
别名:
1-溴-3,3-二甲基-2-丁酮, 溴甲基叔丁基酮
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关于此项目
线性分子式:
(CH3)3CCOCH2Br
化学文摘社编号:
分子量:
179.05
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
226-794-0
Beilstein/REAXYS Number:
506485
MDL number:
产品名称
1-溴频哪酮, technical grade, ~90%
InChI key
SAIRZMWXVJEBMO-UHFFFAOYSA-N
InChI
1S/C6H11BrO/c1-6(2,3)5(8)4-7/h4H2,1-3H3
SMILES string
CC(C)(C)C(=O)CBr
grade
technical grade
assay
~90%
form
liquid
refractive index
n20/D 1.466 (lit.)
bp
188-194 °C (lit.)
mp
−10 °C (lit.)
density
1.331 g/mL at 25 °C (lit.)
functional group
bromo
ketone
storage temp.
2-8°C
Quality Level
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Other Notes
含 1,1-二溴频哪酮和频哪酮
General description
1-Bromopinacolone acts as a reversible competitive inhibitor for acetylcholinesterase in the hydrolysis of acetylcholine.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
167.0 °F - closed cup
flash_point_c
75 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
S G Cohen et al.
Biochimica et biophysica acta, 997(3), 167-175 (1989-08-31)
1-Bromo-2-[14C]pinacolone, (CH3)3C14COCH2Br [( 14C]BrPin), was prepared from [1-14C]acetyl chloride and tert-butylmagnesium chloride with cuprous chloride catalyst, followed by bromination. It was examined as an active-site directed label for acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) (AcChE). AcChE, isolated from Torpedo nobiliana, has
S G Cohen et al.
The Journal of biological chemistry, 257(23), 14087-14092 (1982-12-10)
1-Bromopinacolone, BrPin, acts initially as a reversible competitive inhibitor for acetylcholinesterase, KI = 0.18 mM in hydrolysis of acetylcholine. Unlike bromoacetone, with time it acts as an irreversible covalent inhibitor. BrPin has a hydrolytic half-life of 30 h at the
E Salih et al.
Biochimica et biophysica acta, 1208(2), 324-331 (1994-10-19)
To characterize the structure of the active site of acetylcholinesterase (AChE) from the electric organ of E. electricus, we identified sites of incorporation of two active-site affinity labels, [3H]diisopropyl fluorophosphate ([3H]DFP), and 1-bromo-2-[14C]pinacolone ([14C]BrPin). AChE was isolated, purified, inactivated and
E Salih et al.
The Journal of biological chemistry, 268(1), 245-251 (1993-01-05)
Acetylcholinesterase (AcChE, EC 3.1.1.7) was isolated from the electric organ of T. nobiliana and treated with the active-site-directed alkylating agent 1-bromo-2-[14C]pinacolone ([14C]BrPin), or with BrPin, which acts initially as a competitive inhibitor, Ki = 0.18 mM, and then inactivates the
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