269476
N-乙酰普鲁卡因胺
≥99%
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关于此项目
线性分子式:
4-(CH3CONH)C6H4CONHCH2CH2N(C2H5)2
化学文摘社编号:
分子量:
277.36
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
≥99%
Form:
solid
InChI
1S/C15H23N3O2/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19)
SMILES string
CCN(CC)CCNC(=O)c1ccc(NC(C)=O)cc1
InChI key
KEECCEWTUVWFCV-UHFFFAOYSA-N
assay
≥99%
form
solid
mp
138-140 °C (lit.)
solubility
soluble 1%, clear, colorless to faintly yellow (1N HCl)
functional group
amide, amine
Quality Level
General description
The relaxant effects of N-acetylprocainamide on bovine tracheal smooth muscle was studied.
Application
N-acetylprocainamide (NAPA) was used as a model drug in the study of establishing a quantitative approach to predict the renal clearances of basic drugs using N-1-methylnicotinamide (NMN).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Yoo-Seong Jeong et al.
Pharmaceutics, 11(3) (2019-03-09)
Previous observations demonstrated that cimetidine decreased the clearance of procainamide (PA) and/or N-acetylprocainamide (NAPA; the primary metabolite of PA) resulting in the increased systemic exposure and the decrease of urinary excretion. Despite an abundance of in vitro and in vivo
Multicenter evaluation of the Abbott AxSYM procainamide and N-acetylprocainamide assays: comparison with Abbott TDx/TDxFLx, Syva EMIT 2000, DuPont ACA, and HPLC methods.
H M Azzazy et al.
Clinical biochemistry, 31(1), 55-58 (1998-04-29)
J E Tisdale et al.
Therapeutic drug monitoring, 18(6), 693-697 (1996-12-01)
The objective of this study was to compare the precision and accuracy of fluorescence polarization immunoassay (FPIA) with high-performance liquid chromatography (HPLC) for measurement of procainamide (PA) and N-acetylprocainamide (NAPA) concentrations in urine. To determine the correlation between FPIA and
Y L He et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 13(3), 303-308 (2001-06-01)
The dosage regimen of a drug eliminated predominantly through the kidney need to be adjusted for the patients with renal disease. The objective of the present study was to establish a quantitative approach to precisely predicting the renal clearances of
M Boucher et al.
Journal of autonomic pharmacology, 18(2), 83-87 (1998-09-08)
1. The cardiac anticholinergic effects of procainamide (1 mg kg(-1) min(-1)) and its N-acetylated metabolite (NAPA) at equimolar dose (1.16 mg kg(-1) min(-1)) were studied using in vivo experimental pharmacological and in vitro radioligand binding studies. 2. Procainamide and NAPA
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