269476
N-乙酰普鲁卡因胺
≥99%
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关于此项目
线性分子式:
4-(CH3CONH)C6H4CONHCH2CH2N(C2H5)2
化学文摘社编号:
分子量:
277.36
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
≥99%
Form:
solid
InChI
1S/C15H23N3O2/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19)
SMILES string
CCN(CC)CCNC(=O)c1ccc(NC(C)=O)cc1
InChI key
KEECCEWTUVWFCV-UHFFFAOYSA-N
assay
≥99%
form
solid
mp
138-140 °C (lit.)
solubility
soluble 1%, clear, colorless to faintly yellow (1N HCl)
functional group
amide, amine
Quality Level
General description
The relaxant effects of N-acetylprocainamide on bovine tracheal smooth muscle was studied.
Application
N-acetylprocainamide (NAPA) was used as a model drug in the study of establishing a quantitative approach to predict the renal clearances of basic drugs using N-1-methylnicotinamide (NMN).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Yoo-Seong Jeong et al.
Pharmaceutics, 11(3) (2019-03-09)
Previous observations demonstrated that cimetidine decreased the clearance of procainamide (PA) and/or N-acetylprocainamide (NAPA; the primary metabolite of PA) resulting in the increased systemic exposure and the decrease of urinary excretion. Despite an abundance of in vitro and in vivo
Amitava Dasgupta et al.
Archives of pathology & laboratory medicine, 131(7), 1094-1098 (2007-07-10)
St John's wort induces the activity of the cytochrome P450 enzyme system causing treatment failure because of increased metabolism of many drugs. Procainamide is metabolized by a different pathway to N-acetyl procainamide. To study St John's wort-procainamide interaction using a
Subhash Chandra Ghosh et al.
The Journal of organic chemistry, 77(18), 8007-8015 (2012-08-17)
A practical method for the amidation of aldehydes with economic ammonium chloride or amine hydrochloride salts has been developed for the synthesis of a wide variety of amides by using inexpensive copper sulfate or copper(I) oxide as a catalyst and
Jimmy Flarakos et al.
Analytical chemistry, 77(5), 1345-1353 (2005-03-01)
High-throughput screening of combinatorial libraries has evolved from studying large diverse libraries to analyzing small, structurally similar, focused libraries. This paradigm shift has generated a need for rapid screening technologies to screen both diverse and focused libraries in a simple
J R Koup et al.
Therapeutic drug monitoring, 20(1), 73-77 (1998-03-05)
Procainamide hydrochloride is a Class 1A antiarrhythmic agent administered intravenously or orally for treatment of symptomatic ventricular premature depolarizations (VPD), nonsustained ventricular tachycardia, and life-threatening ventricular arrhythmias. A new sustained-release formulation, Procanbid, which allows for twice-daily dosing was recently approved
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