Merck
CN
所有图片(3)

文件

269476

Sigma-Aldrich

N-乙酰普鲁卡因胺

≥99%

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线性分子式:
4-(CH3CONH)C6H4CONHCH2CH2N(C2H5)2
CAS号:
32795-44-1
分子量:
277.36
MDL编号:
MFCD00009052
PubChem化学物质编号:
24856329
NACRES:
NA.22

质量水平

200

检测方案

≥99%

形式

solid

mp

138-140 °C (lit.)

溶解性

soluble 1%, clear, colorless to faintly yellow (1N HCl)

SMILES string

CCN(CC)CCNC(=O)c1ccc(NC(C)=O)cc1

InChI

1S/C15H23N3O2/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19)

InChI key

KEECCEWTUVWFCV-UHFFFAOYSA-N

相关类别

一般描述

The relaxant effects of N-acetylprocainamide on bovine tracheal smooth muscle was studied.

应用

N-acetylprocainamide (NAPA) was used as a model drug in the study of establishing a quantitative approach to predict the renal clearances of basic drugs using N-1-methylnicotinamide (NMN).

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Yoo-Seong Jeong et al.
Pharmaceutics, 11(3) (2019-03-09)
Previous observations demonstrated that cimetidine decreased the clearance of procainamide (PA) and/or N-acetylprocainamide (NAPA; the primary metabolite of PA) resulting in the increased systemic exposure and the decrease of urinary excretion. Despite an abundance of in vitro and in vivo
Arno G Siraki et al.
Chemical research in toxicology, 21(5), 1143-1153 (2008-05-21)
Procainamide (PA) is a drug that is used to treat tachycardia in postoperative patients or for long-term maintenance of cardiac arrythmias. Unfortunately, its use has also been associated with agranulocytosis. Here, we have investigated the metabolism of PA by myeloperoxidase
F A Brightman et al.
Drug metabolism and disposition: the biological fate of chemicals, 34(1), 94-101 (2005-10-14)
Estimation of xenobiotic kinetics in humans frequently relies upon extrapolation from experimental data generated in animals. In an accompanying paper, we have presented a unique, generic, physiologically based pharmacokinetic model and described its application to the prediction of rat plasma
B B Yang et al.
Journal of clinical pharmacology, 36(7), 623-633 (1996-07-01)
A study was conducted to evaluate the pharmacokinetics of procainamide and its active metabolite, N-acetylprocainamide (NAPA), as a function of dose and formulation and to characterize the relationship between ventricular premature depolarization (VPD) rate and plasma concentrations of procainamide and
T Nakahara et al.
European journal of pharmacology, 415(1), 73-78 (2001-03-14)
We examined the relaxant effects of N-acetylprocainamide, the major hepatic metabolite of procainamide, on bovine tracheal smooth muscle, focusing on the possible involvement of K+ channels. N-acetylprocainamide produced a concentration-dependent and full inhibition of the tension development elicited by methacholine
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