5-甲氧基补骨脂素

Name: 5-甲氧基补骨脂素
Brand: ALDRICH

99%

别名:

4-甲氧基-7H-呋喃并[3,2-g]苯并吡喃-7-酮, 佛手柑内酯

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关于此项目

经验公式（希尔记法）:

C₁₂H₈O₄

化学文摘社编号:

484-20-8

分子量:

216.19

UNSPSC Code:

12352103

NACRES:

NA.23

PubChem Substance ID:

24856667

EC Number:

207-604-5

Beilstein/REAXYS Number:

19560

MDL number:

MFCD00010272

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属性

Quality Level

200

assay

99%

mp

190-193 °C (lit.)

SMILES string

COc1c2C=CC(=O)Oc2cc3occc13

InChI

1S/C12H8O4/c1-14-12-7-2-3-11(13)16-10(7)6-9-8(12)4-5-15-9/h2-6H,1H3

InChI key

BGEBZHIAGXMEMV-UHFFFAOYSA-N

说明

General description

5-Methoxypsoralen (Bergapten) is a high-purity furanocoumarin derivative utilized primarily as a reference standard and photo-reactive probe in advanced biochemical research. At 99% purity, this compound is optimized for studying the mechanisms of photo-activation and nucleic acid intercalation. Its well-defined chemical profile makes it a foundational tool for laboratories investigating the interactions between small molecules, ultraviolet radiation, and cellular pathways.

Application

5-Methoxypsoralen has been studied for its use in oral photochemotherapy in the treatment of psoriasis and other skin diseases.

Features and Benefits

Analytical Grade Purity: A minimum assay of 99% ensures high reproducibility and minimizes interference in sensitive analytical assays or high-throughput screening.
Photo-Reactive Versatility: Serves as a critical reagent for experimental models involving light-induced biological responses, including studies on DNA cross-linking and enzymatic inhibition.
Characterized Standards: Supported by rigorous quality control protocols (HPLC/NMR), providing researchers with the precision required for kinetic and structural studies.
Analytical Standardization & Green Chemistry: Serves as a high-purity (99%) reference standard for calibrating HPLC/MS equipment and validating more sustainable extraction methodologies, such as Supercritical Fluid Extraction (SFE).
Enzyme Kinetics & Signaling: Utilized as a biochemical probe to study acetylcholinesterase (AChE) inhibition and the modulation of cytokine signaling pathways (specifically TNF- and IL-6) in cellular models.
Photo-Reactive Material Science: Investigated for the development of light-activated nanocarriers and photo-responsive polymers for precision-targeted molecular delivery research.
In Vitro Metabolic Modeling: Employed in laboratory assays to investigate the chemical pathways of adipogenesis and the regulation of lipid accumulation within experimental cell lines.
Molecular Interaction Studies: Used to analyze the kinetics of nucleic acid intercalation and the structural dynamics of covalent bonding in furanocoumarin-DNA research.
Biocatalysis Research: Applied as a substrate in studies involving enzyme-catalyzed transformations to explore more eco-friendly chemical synthesis routes.