产品名称
咪唑并[1,2-a]吡啶, 99%
InChI
1S/C7H6N2/c1-2-5-9-6-4-8-7(9)3-1/h1-6H
SMILES string
c1ccn2ccnc2c1
InChI key
UTCSSFWDNNEEBH-UHFFFAOYSA-N
assay
99%
form
liquid
refractive index
n20/D 1.626 (lit.)
bp
103 °C/1 mmHg (lit.)
density
1.165 g/mL at 25 °C (lit.)
Quality Level
General description
在 STIB900 小鼠模型中研究了咪唑并 [1,2-a] 吡啶的体内抗锥虫活性。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Martina Hieke et al.
Bioorganic & medicinal chemistry letters, 22(5), 1969-1975 (2012-02-14)
A novel class of 5-lipoxygenase (5-LO) inhibitors characterized by a central imidazo[1,2-a]pyridine scaffold, a cyclohexyl moiety and an aromatic system, is presented. This scaffold was identified in a virtual screening study and exhibits promising inhibitory potential on the 5-LO. Here
Kyle A Emmitte et al.
Bioorganic & medicinal chemistry letters, 19(3), 1004-1008 (2008-12-23)
The optimization of imidazo[1,2-a]pyridine inhibitors as potent and selective inhibitors of IGF-1R is presented. Further optimization of oral exposure in mice is also discussed. Detailed selectivity, in vitro activity, and in vivo PK profiles of an optimized compound is also
Yoshito Terao et al.
Bioorganic & medicinal chemistry letters, 22(24), 7326-7329 (2012-11-14)
Imidazo[1,2-a]pyridine derivatives were designed, synthesized, and evaluated as inhibitors of the apoptosis signal-regulating kinase 1 (ASK1). These were based on a benzothiazole derivative that was discovered from high-throughput screening of our compound library. As a result, we identified potent, selective
Joanna M Wisniewska et al.
Biochemical pharmacology, 83(2), 228-240 (2011-10-27)
5-Lipoxygenase (5-LO) is a crucial enzyme of the arachidonic acid (AA) cascade and catalyzes the formation of bioactive leukotrienes (LTs) which are involved in inflammatory diseases and allergic reactions. The pathophysiological effects of LTs are considered to be prevented by
Enza Palazzo et al.
Neuropharmacology, 58(3), 660-667 (2009-12-01)
The 6-methoxy-2-phenylimidazo[1,2-b]pyridazine-3-carboxylic acid, DM2, exerts anti-absence activity and blocks Cav3.1 channel, a T-type voltage-dependent Ca(2+) channel subtype, in vitro. The current study investigated the effect of intra-ventrolateral periaqueductal grey (VLPAG) administration of DM2 on formalin-induced nocifensive responses in rats. In
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