278823
4-氯-1-丁醇
technical grade, ~85%
别名:
四亚甲基氯醇
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关于此项目
线性分子式:
HO(CH2)4Cl
化学文摘社编号:
分子量:
108.57
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1731408
产品名称
4-氯-1-丁醇, technical grade, ~85%
InChI
1S/C4H9ClO/c5-3-1-2-4-6/h6H,1-4H2
SMILES string
OCCCCCl
InChI key
HXHGULXINZUGJX-UHFFFAOYSA-N
grade
technical grade
assay
~85%
form
liquid
refractive index
n20/D 1.453 (lit.)
bp
84-85 °C/16 mmHg (lit.)
density
1.088 g/mL at 25 °C (lit.)
functional group
chloro
hydroxyl
storage temp.
2-8°C
Quality Level
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Application
在GC-MS技术中，4-氯-1-丁醇作为内标已被用于活性药物成分中遗传毒性杂质的分析。
General description
4-氯-1-丁醇是一种烷化剂，是活性药物成分中的遗传毒性杂质之一。通过分光光度法对4-氯-1-丁醇和Reichardt染料的反应进行监测，从而测定药物中的遗传毒性杂质。
Other Notes
含四氢呋喃和 HCl
signalword
Warning
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 3 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
supp_hazards
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
96.8 °F - closed cup
flash_point_c
36 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Koki Harigaya et al.
Chemical & pharmaceutical bulletin, 62(4), 395-398 (2014-04-04)
The analysis of genotoxic impurities (GTIs) in active pharmaceutical ingredients (APIs) is a challenging task. The target detection limit (DL) in an API is typically around 1 ppm (1 µg/g API). Therefore, a sensitive and selective analytical method is required for their
Damion K Corrigan et al.
The Journal of pharmacy and pharmacology, 61(4), 533-537 (2009-03-21)
Alkylating agents are potentially genotoxic impurities that may be present in drug products. These impurities occur in pharmaceuticals as by-products from the synthetic steps involved in drug production, as impurities in starting materials or from in-situ reactions that take place
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