279552
4-氯-3-乙基苯酚
97%
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关于此项目
线性分子式:
ClC6H3(C2H5)OH
化学文摘社编号:
分子量:
156.61
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
237-991-6
MDL number:
Assay:
97%
Form:
solid
InChI key
DVKVZPIRWWREJC-UHFFFAOYSA-N
InChI
1S/C8H9ClO/c1-2-6-5-7(10)3-4-8(6)9/h3-5,10H,2H2,1H3
SMILES string
CCc1cc(O)ccc1Cl
assay
97%
form
solid
mp
45-50 °C (lit.)
functional group
chloro
Application
4-Chloro-3-ethylphenol is a ryanodine receptor antagonist and is commonly used as research tool and diagnostic reagent for malignant hyperthermia.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
L J Janssen et al.
The American journal of physiology, 276(5 Pt 1), L744-L753 (1999-05-18)
We examined cytosolic concentration of Ca2+ ([Ca2+]i) in canine airway smooth muscle using fura 2 fluorimetry (global changes in [Ca2+]i), membrane currents (subsarcolemmal [Ca2+]i), and contractions (deep cytosolic [Ca2+]i). Acetylcholine (10(-4) M) elicited fluorimetric, electrophysiological, and mechanical responses. Caffeine (5
Aniko Varadi et al.
Diabetes, 51 Suppl 1, S190-S201 (2002-01-30)
The endoplasmic reticulum (ER) plays a pivotal role in the regulation of cytosolic Ca(2+) concentrations ([Ca(2+)](cyt)) and hence in insulin secretion from pancreatic beta-cells. However, the molecular mechanisms involved in both the uptake and release of Ca(2+) from the ER
Francisco H Andrade et al.
Investigative ophthalmology & visual science, 46(12), 4541-4547 (2005-11-24)
The ultrafast extraocular muscles necessitate tight regulation of free cytosolic Ca2+ concentration ([Ca2+]i). Mitochondrial Ca2+ influx may be fast enough for this role. In the present study, three hypotheses were tested: (1) Mitochondrial Ca2+ uptake regulates [Ca2+]i and production of
A M Low et al.
British journal of pharmacology, 122(3), 504-510 (1997-11-14)
1. Recently, 4-chloro-3-ethyl phenol (CEP) has been shown to cause the release of internally stored Ca2+ apparently through ryanodine-sensitive Ca2+ channels, in fractionated skeletal muscle terminal cisternae and in a variety of non-excitable cell types. Its action on smooth muscle
Bo Zeng et al.
British journal of pharmacology, 171(5), 1250-1259 (2014-03-29)
Depletion of the Ca(2+) store by ryanodine receptor (RyR) agonists induces store-operated Ca(2+) entry (SOCE). 4-Chloro-3-ethylphenol (4-CEP) and 4-chloro-m-cresol (4-CmC) are RyR agonists commonly used as research tools and diagnostic reagents for malignant hyperthermia. Here, we investigated the effects of
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