280550
双苯比拉林 盐酸盐
95%
别名:
4-二苯甲氧基-1-甲基哌啶, 二苯拉林 盐酸盐
质量水平
方案
95%
mp
203-205 °C (lit.)
官能团
ether
phenyl
SMILES字符串
Cl[H].CN1CCC(CC1)OC(c2ccccc2)c3ccccc3
InChI
1S/C19H23NO.ClH/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18-19H,12-15H2,1H3;1H
InChI key
LPRLDRXGWKXRMQ-UHFFFAOYSA-N
基因信息
human ... HRH1(3269)
一般描述
4-Diphenylmethoxy-1-methylpiperidine hydrochloride is also referred as diphenylpyraline hydrochloride (DPP), is a first-generation antihistamine.
应用
4-Diphenylmethoxy-1-methylpiperidine hydrochloride was used as a pharmacotherapy for Parkinson′s disease.
Chika Hasegawa et al.
Rapid communications in mass spectrometry : RCM, 20(4), 537-543 (2006-01-19)
Ten antihistamine drugs, diphenhydramine, orphenadrine, chlorpheniramine, diphenylpyraline, triprolidine, promethazine, homochlorcyclizine, cyproheptadine, cloperastine and clemastine, have been found to be extractable from human plasma samples using MonoTip C18 tips, inside which C18- bonded monolithic silica gel was fixed. Human plasma (0.1
K O Ebete et al.
Journal of chromatography. B, Biomedical applications, 677(2), 319-323 (1996-03-03)
A rapid, reliable and specific reversed-phase high-performance liquid chromatographic procedure is described for the determination of diphenylpyraline hydrochloride at nanogram concentrations in plasma and urine. After extraction of the drug with n-pentane-2-propanol (50:1) from alkalinized samples, the organic extract was
T Ohno et al.
Journal of the neurological sciences, 182(2), 95-97 (2001-01-04)
A long-term follow-up study was made of three patients with cerebrotendinous xanthomatosis (CTX) associated with parkinsonism, two of whom were siblings. Besides typical CTX symptoms, all three patients showed severe parkinsonism. This observation has been rarely reported in CTX. The
N Shibata et al.
Rinsho shinkeigaku = Clinical neurology, 30(9), 978-984 (1990-09-01)
Two sibling cases of cerebrotendinous xanthomatosis with parkinsonism were reported. One was a woman of 39 years old, and another was her sister of 36 years old. In both cases, febrile convulsion appeared on 1.5 year old, and mental deterioration
M A Lung et al.
Rhinology, 25(2), 95-100 (1987-06-01)
The effects of three commonly used H1 antihistamines on the nasal vascular and airway resistances were studied in the dog. Promethazine hydrochloride decreased nasal vascular resistance but increased nasal airway resistance in a dose-dependent manner. Diphenylpyraline hydrochloride in low doses
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