284270
磷酰基乙酸
98%
别名:
(羧甲基)膦酸, 2-磷酰基乙酸, 磷酰基乙酸
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关于此项目
线性分子式:
(HO)2P(O)CH2CO2H
化学文摘社编号:
分子量:
140.03
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
224-558-1
MDL number:
Assay:
98%
Form:
powder or crystals
InChI key
XUYJLQHKOGNDPB-UHFFFAOYSA-N
InChI
1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7)
SMILES string
OC(=O)CP(O)(O)=O
assay
98%
form
powder or crystals
mp
143-146 °C (lit.)
solubility
water: soluble 100 mg/mL, clear to very slightly hazy, colorless
functional group
carboxylic acid
Quality Level
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General description
膦酰基乙酸可在病毒感染的人成纤维细胞中抑制特异性的人巨细胞病毒DNA合成。它还能够抑制感染细胞中单纯疱疹病毒DNA的合成以及在体外病毒特异性DNA聚合酶的活性。
Application
膦酰基乙酸已被用作病毒DNA复制的一种抑制剂，以研究受感染的低传代牛细胞中感染细胞蛋白0（bICP0）的定位。它还可以磷酸盐非依赖性方式用作微生物生长的一种磷源。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Journal of molecular biology, 400(3), 295-308 (2010-05-25)
Structure-based protein sequence alignments of family B DNA polymerases revealed a conserved motif that is formed from interacting residues between loops from the N-terminal and palm domains and between the N-terminal loop and a conserved proline residue. The importance of
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Virus-host interactions are frequently studied in bulk cell populations, obscuring cell-to-cell variation. Here we investigate endogenous herpesvirus gene expression at the single-cell level, combining a sensitive and robust fluorescent in situ hybridization platform with multiparameter flow cytometry, to study the
A Abendroth et al.
Journal of virology, 75(10), 4878-4888 (2001-04-20)
We sought to examine the effects of varicella-zoster virus (VZV) infection on the expression of major histocompatibility complex class I (MHC I) molecules by human fibroblasts and T lymphocytes. By flow cytometry, VZV infection reduced the cell surface expression of
T Sairenji et al.
The Journal of general virology, 38(1), 111-120 (1978-01-01)
This study investigated the synthesis of membrane antigen (MA) as well as virus capsid antigen (VCA) and early antigen (EA) in Daudi cells which had been superinfected with the P3HR-1 strain of Epstein-Barr virus (EBV) and then treated with trypsin
Adam D Lietzan et al.
Biochemistry, 50(45), 9708-9723 (2011-10-01)
Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues. To effect catalysis, the tethered biotin of PC must gain access to active sites in both the biotin carboxylase domain and the
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