284327
1,6-二硝基芘
98%
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关于此项目
经验公式（希尔记法）:
C16H8N2O4
化学文摘社编号:
分子量:
292.25
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
InChI
1S/C16H8N2O4/c19-17(20)13-8-4-10-2-6-12-14(18(21)22)7-3-9-1-5-11(13)16(10)15(9)12/h1-8H
SMILES string
[O-][N+](=O)c1ccc2ccc3c(ccc4ccc1c2c34)[N+]([O-])=O
InChI key
GUXACCKTQWVTLG-UHFFFAOYSA-N
assay
98%
mp
>300 °C (lit.)
General description
1,6-Dinitropyrene is a potent mutagenic components of diesel exhaust and air pollutant. 1,6-Dinitropyrene is an extremely potent genotoxicant in metabolically competent primary cultures of human and rat hepatocytes.
signalword
Danger
hcodes
Hazard Classifications
Carc. 1B
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
B E Butterworth et al.
Mutation research, 122(1), 73-80 (1983-10-01)
1,6-Dinitropyrene (DNP) was found to be an extremely potent genotoxicant in metabolically competent primary cultures of human and rat hepatocytes. Dose-dependent increases in DNA repair as measured by unscheduled DNA synthesis (UDS) were observed in the range from 0.05 to
F Kiefer et al.
Toxicology letters, 96-97, 131-136 (1998-11-20)
The effect of caffeine on the genotoxicity of several carcinogenic compounds representing various classes of chemicals was investigated in a panel of V79 Chinese hamster cells genetically engineered to express cytochromes P4501A1 and P4501A2 and differing in their expression of
K Singletary et al.
Cancer letters, 155(1), 47-54 (2000-05-18)
Numerous phytochemicals have been examined for their capacity to act as cancer chemopreventive agents. Dibenzoylmethane, a minor constituent of licorice and a compound structurally-related to curcumin, recently was identified as an effective inhibitor of chemically-induced rat mammary DNA-adduct formation and
I Tahara et al.
Mutation research, 343(2-3), 109-119 (1995-06-01)
This study examined the stability of mutagenic 1-nitropyrene (1-NP) and (1,6-dinitropyrene (1,6-diNP) in environmental water samples and various soil suspensions containing 0.1% peptone and in water samples containing no peptone. The water samples or the soil suspensions were mixed with
I B Lambert et al.
Mutagenesis, 13(1), 9-18 (1998-03-10)
We have examined the mutational specificity of 1-nitroso-6-nitropyrene (1,6-NONP), an activated metabolite of the carcinogen 1,6-dinitropyrene, in the lacI gene of Escherichia coli strains which are deficient in nucleotide excision repair (strain NR6113, delta uvrB; strain CM6114, delta uvrB, plasmid
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