284718
(-)-可替宁
98%
别名:
(S)-1-甲基-5-(3-吡啶基)-2-吡咯烷酮, S(-)-1-甲基-5-(3-吡啶基)-2-吡咯烷酮
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关于此项目
经验公式（希尔记法）:
C10H12N2O
化学文摘社编号:
分子量:
176.22
EC Number:
207-634-9
UNSPSC Code:
12352103
PubChem Substance ID:
Beilstein/REAXYS Number:
83099
MDL number:
InChI key
UIKROCXWUNQSPJ-VIFPVBQESA-N
InChI
1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1
SMILES string
CN1[C@@H](CCC1=O)c2cccnc2
assay
98%
optical activity
[α]20/D −21°, c = 1 in ethanol
bp
250 °C/150 mmHg (lit.)
mp
40-42 °C (lit.)
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Biochem/physiol Actions
尼古丁在人体内的主要代谢物。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
flash_point_f
230.0 °F - closed cup
flash_point_c
110 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
存储类别
11 - Combustible Solids
法规信息
新产品
此项目有
Ines Moreno-Gonzalez et al.
Nature communications, 4, 1495-1495 (2013-02-21)
Several epidemiological studies have shown that cigarette smoking might alter the incidence of Alzheimer's disease. However, inconsistent results have been reported regarding the risk of Alzheimer's disease among smokers. Previous studies in experimental animal models have reported that administration of
V Haufroid et al.
International archives of occupational and environmental health, 71(3), 162-168 (1998-05-20)
A minireview is presented concerning the use of cotinine as a tobacco-smoke exposure index. First, general considerations about methods for the determination of urinary cotinine are presented. Besides pure analytical aspects, this minireview considers major problems encountered in the establishment
Sarah Connor Gorber et al.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 11(1), 12-24 (2009-02-28)
Smoking is a leading cause of premature mortality and preventable morbidity. Surveillance is most often based on self-reported data, but studies have shown that self-reports tend to underestimate smoking status. This study systematically reviewed the literature to measure the concordance
Natalie S Shenker et al.
Epidemiology (Cambridge, Mass.), 24(5), 712-716 (2013-07-23)
Most biomarkers of exposure tend to have short half-lives. This includes cotinine, a metabolite of nicotine widely used to assess smoke exposure. Cotinine is thus unsuitable as a determinant of past exposure to cigarette smoke. We used bisulphite pyrosequencing of
Cotinine as a biomarker of environmental tobacco smoke exposure.
N L Benowitz
Epidemiologic reviews, 18(2), 188-204 (1996-01-01)
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