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286044

肉叶云香碱

Name: 肉叶云香碱
Brand: ALDRICH

98%

别名:

7-甲氧基-1-甲基-9H-吡啶并[3,4-b]吲哚

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关于此项目

经验公式（希尔记法）:

C₁₃H₁₂N₂O

化学文摘社编号:

442-51-3

分子量:

212.25

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24857229

EC Number:

207-131-4

Beilstein/REAXYS Number:

178813

MDL number:

MFCD00004958

Assay:

98%

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属性

description

Drug Control: Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet.

Quality Level

100

assay

98%

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

mp

262-264 °C (lit.)

SMILES string

CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3

InChI

1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3

InChI key

BXNJHAXVSOCGBA-UHFFFAOYSA-N

Gene Information

human ... CDC2(983), CYP2D6(1565)

说明

General description

The combination index (CI, serves as a quantitative indicator of pharmacological interactions) for harmaline/harmine and methylene blue/harmine was studied.

Application

Harmine was used as a donor in the fluorescence resonance energy transfer (FRET) study between harmine and silver nanoparticles (AgNPs).

Biochem/physiol Actions

中枢神经系统兴奋剂。

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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分析证书(COA)

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Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma.

Katie L Uhl et al.

Cancer cell international, 18, 82-82 (2018-07-07)

Neuroblastoma (NB) is an early childhood malignancy that arises from the developing sympathetic nervous system. Harmine is a tricyclic β-carboline alkaloid isolated from the harmal plant that exhibits both cytostatic and cytotoxic effects. Harmine is capable of blocking the activities

Inhibition of monoamine oxidase (MAO) by β-carbolines and their interactions in live neuronal (PC12) and liver (HuH-7 and MH1C1) cells.

Michael F Santillo et al.

Toxicology in vitro : an international journal published in association with BIBRA, 28(3), 403-410 (2014-01-01)

Interactions among monoamine oxidase (MAO) inhibitors in drugs, botanicals, and dietary supplements may lead to unpredictable neurochemical dysfunction due to excessive inhibition or therapeutic invalidation. Often recombinant MAO or brain tissue homogenates have been used to evaluate MAO inhibitors such

Novel trisubstituted harmine derivatives with original in vitro anticancer activity.

Raphaël Frédérick et al.

Journal of medicinal chemistry, 55(14), 6489-6501 (2012-07-10)

To overcome the intrinsic resistance of cancer cells to apoptotic stimuli, we designed and synthesized approximately 50 novel β-carbolines structurally related to harmine. Harmine is known for its anticancer properties and is a DYRK1A inhibitor. Of the synthesized compounds, the

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全球贸易项目编号

货号	GTIN
286044-1G	04061826259689