299634
6-(5H)-菲啶酮
technical grade
别名:
NSC 11021, NSC 40943, NSC 61083
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关于此项目
经验公式（希尔记法）:
C13H9NO
化学文摘社编号:
分子量:
195.22
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
213-804-3
MDL number:
Form:
powder
grade
technical grade
form
powder
mp
290-292 °C (lit.)
SMILES string
O=C1Nc2ccccc2-c3ccccc13
InChI
1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15)
InChI key
RZFVLEJOHSLEFR-UHFFFAOYSA-N
Gene Information
human ... PARP1(142)
General description
6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.
Application
Reactant involved in:
Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including:
- Synthesis of 5,6-dihydrophenanthridine sulfonamides
- Oxidative coupling with diphenylacetylene
- Direct copper acetate-catalyzed N-cyclopropylation of cyclic amides
Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including:
- Potassium channel KV1.3 and IK-1 inhibitors
- HIV-1 integrase inhibitors
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Miriam León Paumen et al.
Environmental science & technology, 42(9), 3434-3440 (2008-06-05)
This study aimed to monitor PAC availability to the oligochaete Lumbriculus variegatus during 28 days of exposure to spiked sediments, in order to obtain reliable chronic effect concentrations for reproduction. Sediment toxicity tests were performed using three pairs of PAC
Alberto Chiarugi
British journal of pharmacology, 137(6), 761-770 (2002-11-02)
1. In the presence of genotoxic stress poly(ADP-ribose) polymerase-1 (PARP-1) leads to NAD(+) and ATP depletion, participating in the pathogenesis of several disorders including inflammation. Accordingly, chemical inhibitors of PARP-1 are efficacious anti-inflammatories, albeit the underlying molecular mechanisms are still
F Moroni et al.
Cell death and differentiation, 8(9), 921-932 (2001-08-30)
An excessive activation of poly(ADP-ribose) polymerase (PARP) has been proposed to play a key role in post-ischemic neuronal death. We examined the neuroprotective effects of the PARP inhibitors benzamide, 6(5H)-phenanthridinone, and 3,4-dihydro-5-[4-1(1-piperidinyl)buthoxy]-1(2H)-isoquinolinone in three rodent models of cerebral ischemia. Increasing
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 299634-1G | 04061826238905 |