318035
(S)-(-)-α-甲氧基-α-(三氟甲基)苯乙酸
≥99%
别名:
(-)-MTPA, Mosher 酸
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关于此项目
线性分子式:
C6H5C(OCH3)(CF3)CO2H
化学文摘社编号:
分子量:
234.17
UNSPSC Code:
12352112
NACRES:
NA.22
PubChem Substance ID:
EC Number:
241-292-1
Beilstein/REAXYS Number:
4684048
MDL number:
Assay:
≥99%
产品名称
(S)-(-)-α-甲氧基-α-(三氟甲基)苯乙酸, ≥99%
InChI key
JJYKJUXBWFATTE-VIFPVBQESA-N
InChI
1S/C10H9F3O3/c1-16-9(8(14)15,10(11,12)13)7-5-3-2-4-6-7/h2-6H,1H3,(H,14,15)/t9-/m0/s1
SMILES string
CO[C@](C(O)=O)(c1ccccc1)C(F)(F)F
assay
≥99%
optical activity
[α]18/D −72°, c = 1.6 in methanol
optical purity
ee: 99% (GLC)
refractive index
n20/D 1.474 (lit.)
bp
95-97 °C/0.05 mmHg (lit.)
mp
46-49 °C (lit.)
density
1.303 g/mL at 25 °C (lit.)
functional group
carboxylic acid
ether
fluoro
phenyl
storage temp.
2-8°C
Quality Level
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General description
(S)-(-)-α-甲氧基-α-(三氟甲基)苯乙酸通常用作 Mosher 酯分析和 Mosher 酰胺分析中的衍生剂，这是基于核磁共振法分别测定仲醇和胺类化合物中手性碳中心绝对构型的方法。
Other Notes
doi:10.1038/nprot.2007.354
Packaging
无底玻璃瓶。内含物在插入的融合锥体内。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons.
Hoye TR, et al.
Nature Protocols, 2(10), 2451-2458 (2007)
Bin Sui et al.
The Journal of organic chemistry, 75(9), 2942-2954 (2010-04-17)
Two different mixture synthesis routes have been used to make the four stereoisomers of petrocortyne A. A first quick and dirty route provided a mixture of the four isomers in nonselective fashion. Mosher and 2-naphthylmethoxyacetic acid (NMA) ester methods were
D B Matthews et al.
Journal of chromatography. B, Biomedical sciences and applications, 695(2), 279-285 (1997-08-01)
Methods for the nuclear magnetic resonance and gas chromatographic analysis of the enantiomers of p-trifluoromethylmandelic acid (p-TFM) and Mosher's acid (alpha-methoxy-alpha-(trifluoromethyl)phenylacetic acid) present in rat urine samples are described. Gas chromartography was performed using cyclodextrin capillary columns with both compounds
J Martín Torres-Valencia et al.
Phytochemical analysis : PCA, 13(6), 329-332 (2002-12-24)
A method to determine the absolute configuration of 2,3-epoxy-2-methylbutanoate ester residues in natural products is presented, based on (i) the reduction of the ester function to yield a 2-methyl-1,2-butanediol, (ii) esterification of the obtained primary alcohol with either (R)-(+)- or
Giancarlo Cravotto et al.
Chirality, 16(8), 526-533 (2004-08-04)
Cyclodextrin (CD) derivatives are important selectors for analytical chiral recognition. Their enantioselectivities and chemical properties depend on ring size and on nature, number and location of substituents. This paper describes the synthesis of 6-O-TBDMS-2,3-O-methyl beta-cyclodextrins bearing in position 2 either
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