327190
亚硝酸异丁酯
95%
别名:
2-亚硝酸甲丙酯
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关于此项目
线性分子式:
(CH3)2CHCH2ONO
化学文摘社编号:
分子量:
103.12
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
208-819-7
MDL number:
Assay:
95%
Form:
liquid
InChI key
APNSGVMLAYLYCT-UHFFFAOYSA-N
InChI
1S/C4H9NO2/c1-4(2)3-7-5-6/h4H,3H2,1-2H3
SMILES string
CC(C)CON=O
assay
95%
form
liquid
refractive index
n20/D 1.373 (lit.)
bp
66-67 °C (lit.)
density
0.87 g/mL at 25 °C (lit.)
functional group
O-nitroso, nitroso
storage temp.
2-8°C
Quality Level
General description
亚硝酸异丁酯广泛用作室内除臭剂。这是一种流行的娱乐药物。
Application
亚硝酸异丁酯用于研究吸入剂诱导的免疫毒性。
signalword
Danger
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Flam. Liq. 2 - Muta. 2
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
-5.8 °F - closed cup
flash_point_c
-21 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
[Methemoglobinemia due to ingestion of isobutyl nitrite ('poppers')].
W G Zijlstra
Nederlands tijdschrift voor geneeskunde, 147(23), 1144-1144 (2003-06-26)
M T C Pruijm et al.
Nederlands tijdschrift voor geneeskunde, 146(49), 2370-2373 (2003-01-04)
Two male students, aged 20 and 21 years, developed central cyanosis shortly after drinking 5 ml of 'poppers' (isobutyl nitrite). They presented with methaemoglobinaemia and were hospitalised. After treatment with oxygen and intravenous fluids they could be discharged in good
S M Bradberry et al.
Journal of toxicology. Clinical toxicology, 32(2), 179-184 (1994-01-01)
Isobutyl nitrite is a popular recreational drug among both homosexuals and heterosexuals as it is alleged to enhance sexual pleasure and prolong orgasm. In contrast to the ingestion of this volatile nitrite, inhalation is associated only rarely with serious sequelae
Lee S F Soderberg et al.
Toxicology letters, 132(1), 37-45 (2002-06-27)
Nitrite inhalant abuse has been correlated with HIV and Kaposi's sarcoma. Mouse models of inhalant exposure show immunosuppression and loss of immune cells. In the present study, isobutyl nitrite caused a dose-dependent loss of viability of a macrophage cell line.
L S F Soderberg et al.
Toxicology letters, 152(1), 47-56 (2004-08-06)
Epidemiological studies have identified abuse of nitrite inhalants as an independent co-factor in HIV infection and in Kaposi's sarcoma (KS) in AIDS patients. In the present study we investigated the ability of macrophages from mice exposed to isobutyl nitrite to
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