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经验公式(希尔记法):
C6H10O4
化学文摘社编号:
分子量:
146.14
UNSPSC Code:
12352201
NACRES:
NA.22
PubChem Substance ID:
EC Number:
211-492-3
Beilstein/REAXYS Number:
80510
MDL number:
InChI key
KLDXJTOLSGUMSJ-JGWLITMVSA-N
InChI
1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1
SMILES string
O[C@H]1CO[C@@H]2[C@H](O)CO[C@H]12
assay
98%
form
solid
optical activity
[α]20/D +45.2°, c = 3 in H2O
Quality Level
Application
二脱水-D-山梨糖醇是一种更环保的成分,被广泛用作各种医疗和制药用聚合物和功能材料的单体和结构单元。它还可用作燃料或燃料添加剂。
应用包括:
应用包括:
- 制备可再生聚酯,用于涂料应用。
- 合成异山梨醇酯,如低聚(己二酸异山梨酯)(OSA)、低聚(异山梨醇辛二酸酯)(OSS)和异山梨醇二己酸酯(SDH),作为邻苯二甲酸酯增塑剂的可再生替代品。
- 合成可生物降解多孔聚氨酯支架,用于组织修复和再生。
- 合成阿司匹林前药,即异山梨醇-2,5-二水杨酸(ISDA)。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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To evaluate and compare the effects of oral isosorbide and glycerol on intraocular pressure (IOP), serum osmolality (SOSM), and blood glucose (BG) in normal dogs. Ten normal dogs were administered an oral dose of either isosorbide (1.5 g/kg), glycerol (1.5g/kg)
Jonathan Lai et al.
ChemSusChem, 4(8), 1104-1111 (2011-07-19)
The telomerisation of 1,3-butadiene with a Pd/TPPTS catalytic system in water or an organic solvent was used for the synthesis of C8 ethers from isosorbide, an agro-based diol. The use of water/oil biphasic reaction conditions allowed the selective synthesis of
Discovery of a ?true? aspirin prodrug.
Moriarty LM, et al.
Journal of Medicinal Chemistry, 51(24), 7991-7999 (2008)
Bleeding from ruptured oesophageal varices: propranolol for primary prevention.
Prescrire international, 21(125), 73-77 (2012-03-21)
Xiaoli Wang et al.
Journal of medicinal chemistry, 56(7), 3078-3089 (2013-03-21)
In search of novel anti-ischemic stroke agents with higher potency than a known drug 3-n-butylphthalide (NBP), a series of hybrids ((S)- and (R)-5a-f) from optically active ring-opened NBP derivative and isosorbide were synthesized for evaluating their anti-ischemic stroke activity. Compound
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