333328
6-乙氧基-2-苯并噻唑磺酰胺
97%
别名:
6-乙氧基-2-苯并噻唑磺酰胺, 依索唑胺
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关于此项目
经验公式（希尔记法）:
C9H10N2O3S2
化学文摘社编号:
分子量:
258.32
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
207-199-5
MDL number:
Assay:
97%
Form:
solid
InChI key
OUZWUKMCLIBBOG-UHFFFAOYSA-N
InChI
1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
SMILES string
CCOc1ccc2nc(sc2c1)S(N)(=O)=O
assay
97%
form
solid
mp
190-193 °C (lit.)
Gene Information
human ... CA1(759), CA12(771), CA13(377677), CA14(23632), CA2(760), CA3(761), CA4(762), CA5A(763), CA5B(11238), CA6(765), CA7(766), CA9(768)
mouse ... Car5a(12352)
General description
6-乙氧基-2-苯并噻唑磺酰胺是一种膜渗透性碳酸酐酶抑制剂，已在正常白兔中对其眼部分布和药理学进行了研究。在体外引起抑制胰岛素降解 。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Holger M Becker et al.
The Journal of biological chemistry, 282(18), 13508-13521 (2007-03-14)
Several acid/base-coupled membrane transporters, such as the electrogenic sodium-bicarbonate cotransporter (NBCe1), have been shown to bind to different carbonic anhydrase isoforms to create a "transport metabolon." We have expressed NBCe1 derived from human kidney in oocytes of Xenopus leavis and
N A Tobey et al.
American journal of physiology. Gastrointestinal and liver physiology, 293(1), G264-G270 (2007-04-14)
The human esophagus is lined by stratified squamous epithelium (ESSE), and in some subjects with reflux disease the distal esophagus becomes lined by Barrett's specialized columnar epithelium (BSCE). ESSE and BSCE differ both histologically and functionally, the latter evident by
Studies of the effect of carbutamide on glucose-6-phosphatase.
C A KUETHER et al.
Diabetes, 6(1), 23-25 (1957-01-01)
Jatinder Kaur et al.
Journal of medicinal chemistry, 63(17), 9540-9562 (2020-08-14)
Vancomycin-resistant enterococci (VRE) are the second leading cause of hospital-acquired infections (HAIs) attributed to a drug-resistant bacterium in the United States, and resistance to the frontline treatments is well documented. To combat VRE, we have repurposed the FDA-approved carbonic anhydrase
Andreza Ribeiro et al.
Journal of the Royal Society, Interface, 9(74), 2059-2069 (2012-04-12)
Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application. Three highly hydrophilic varieties of poloxamine (T908, T1107 and T1307) and a medium hydrophilic variety (T904)
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