333328
6-乙氧基-2-苯并噻唑磺酰胺
97%
别名:
6-乙氧基-2-苯并噻唑磺酰胺, 依索唑胺
方案
97%
表单
solid
mp
190-193 °C (lit.)
SMILES字符串
CCOc1ccc2nc(sc2c1)S(N)(=O)=O
InChI
1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
InChI key
OUZWUKMCLIBBOG-UHFFFAOYSA-N
基因信息
human ... CA1(759), CA12(771), CA13(377677), CA14(23632), CA2(760), CA3(761), CA4(762), CA5A(763), CA5B(11238), CA6(765), CA7(766), CA9(768)
mouse ... Car5a(12352)
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一般描述
6-乙氧基-2-苯并噻唑磺酰胺是一种膜渗透性碳酸酐酶抑制剂，已在正常白兔中对其眼部分布和药理学进行了研究。在体外引起抑制胰岛素降解 。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Basel H Abuaita et al.
Infection and immunity, 77(9), 4111-4120 (2009-07-01)
Vibrio cholerae is a gram-negative bacterium that is the causative agent of cholera, a severe diarrheal illness. The two biotypes of V. cholerae O1 capable of causing cholera, classical and El Tor, require different in vitro growth conditions for induction
Xenia Filip et al.
Physical chemistry chemical physics : PCCP, 13(40), 17978-17986 (2011-09-21)
A solid state structural investigation of ethoxzolamide is performed on microcrystalline powder by using a multi-technique approach that combines X-ray powder diffraction (XRPD) data analysis based on direct space methods with information from (13)C((15)N) solid-state Nuclear Magnetic Resonance (SS-NMR) and
Eric T Mack et al.
Journal of the American Chemical Society, 134(1), 333-345 (2011-11-18)
This paper describes a synthetic dimer of carbonic anhydrase, and a series of bivalent sulfonamide ligands with different lengths (25 to 69 Å between the ends of the fully extended ligands), as a model system to use in examining the
Kerry L Peña et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(6), 2455-2460 (2010-02-06)
Cyanobacterial RuBisCO is sequestered in large, icosahedral, protein-bounded microcompartments called carboxysomes. Bicarbonate is pumped into the cytosol, diffuses into the carboxysome through small pores in its shell, and is then converted to CO(2) by carbonic anhydrase (CA) prior to fixation.
Andreza Ribeiro et al.
Journal of the Royal Society, Interface, 9(74), 2059-2069 (2012-04-12)
Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application. Three highly hydrophilic varieties of poloxamine (T908, T1107 and T1307) and a medium hydrophilic variety (T904)
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