Merck
CN
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文件

341738

Sigma-Aldrich

磺酰罗丹明 B，酸式

laser grade, Dye content 95 %

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经验公式（希尔记法）:
C27H30N2O7S2
CAS号:
2609-88-3
分子量:
558.67
EC 号:
220-025-2
MDL编号:
MFCD00067690
PubChem化学物质编号:
57649121
NACRES:
NA.23

等级

laser grade

质量水平

200

形式

solid

组成

Dye content, 95%

mp

>300 °C (lit.)

λmax

558 nm

SMILES字符串

CCN(CC)c1ccc2c(OC3=CC(\C=CC3=C2c4ccc(cc4S([O-])(=O)=O)S(O)(=O)=O)=[N+](/CC)CC)c1

InChI

1S/C27H30N2O7S2/c1-5-28(6-2)18-9-12-21-24(15-18)36-25-16-19(29(7-3)8-4)10-13-22(25)27(21)23-14-11-20(37(30,31)32)17-26(23)38(33,34)35/h9-17H,5-8H2,1-4H3,(H-,30,31,32,33,34,35)

InChI key

IOOMXAQUNPWDLL-UHFFFAOYSA-N

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相关类别

一般描述

磺酰罗丹明 B (SRB) 是一种荧光蛋白染料。 据报告，染料在温和的碱性条件下与三氯乙酸固定细胞的氨基酸残基结合，并在温和的酸性条件下将其自身提取到溶液中。

应用

SRB 对其对活细胞反应性的 pH 敏感性使其可用于药物诱导的细胞毒性和细胞增殖。SRB 实验用于监测活细胞的酶活性。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Wieland Voigt
Methods in molecular medicine, 110, 39-48 (2005-05-20)
The sulforhodamine B (SRB) assay was developed by Skehan and colleagues to measure drug-induced cytotoxicity and cell proliferation for large-scale drug-screening applications. Its principle is based on the ability of the protein dye sulforhodamine B to bind electrostatically and pH
Efficacy of 5-FU or Oxaliplatin Monotherapy over Combination Therapy in Colorectal Cancer.
Toloudi M, et al.
Journal of Cancer Therapy, 6(4), 345-345 (2015)
Xinyuan Chen et al.
Journal of controlled release : official journal of the Controlled Release Society, 159(1), 43-51 (2012-01-21)
Full-surface laser ablation has been shown to efficiently disrupt stratum corneum and facilitate transcutaneous drug delivery, but it is frequently associated with skin damage that hampers its clinic use. We show here that a safer ablative fractional laser (AFL) can
Y Fujinami et al.
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Passive smoking is the involuntary inhalation of cigarette smoke (CS) and has an adverse impact on oral health. We examined the effect of CS exposure on caries risk and experimental dental caries. Experimental dental caries was induced in rat maxillary
Fujun Han et al.
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