Application
1-甲基-3-硝基胍（ N -甲基- N′-硝基胍）用于氯噻尼定半抗原的合成。
General description
在黄嘌呤氧化酶系统中，1-甲基-3-硝基-1-亚硝基胍 (MNG) 诱发胃癌的过程中，MNG 作为中间产物生成羟基自由基。美国空军武器实验室已将 MNG 用于爆炸物配方。MNG 是在 H2O2 对 MNNG 的亚硝基氮进行亲核进攻过程中形成的。MNG 是 N -甲基- N′ 的非致癌性类似物-硝基- N -亚硝基胍（直接作用的致癌物）。
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Sol. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
4.1B - Flammable solid hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
T Mikuni et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 70(3-4), 262-268 (1992-03-01)
We examined hydroxyl free radical (.OH) production in the mixture of H2O2 and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) without exposure to light using the electron spin resonance spin-trapping technique. When the mixtures were protected from exposure to light, .OH was formed at pH
Van Hanh Vu et al.
Journal of microbiology and biotechnology, 20(4), 718-726 (2010-05-15)
A selected fungal strain, for production of the raw-starchdigesting enzyme by solid-state fermentation, was improved by two repeated sequential exposures to gamma-irradiation of Co60, ultraviolet, and four repeated treatments with Nmethyl- N'-nitrosoguanidine. The mutant strain Aspergillus sp. XN15 was chosen
Akihisa Abe et al.
Microbiological research, 162(2), 130-138 (2006-03-08)
The viable but nonculturable (VBNC) suppression mutant formed platable cells at low temperature stress after inoculation in artificial seawater (ASW). Suppression subtractive hybridization was used to identify differentially expressed genes among cDNAs of the VBNC suppression mutant and the wild-type
E R Kinkead et al.
Toxicology and industrial health, 9(3), 457-477 (1993-05-01)
Currently, N-methyl-N'-nitroguanidine (MNG) is being considered by the U.S. Air Force Armament Laboratory for use in explosive formulations. A mammalian toxicity profile has been performed which includes the analysis of chemical impurities and an assessment of the potential for the
A W Hsie et al.
Molecular toxicology, 1(2-3), 217-234 (1987-04-01)
Previously, we have shown that Chinese hamster ovary (CHO) cells are useful for quantifying chemical-induced gene mutations. We have defined the conditions of a Multiplex CHO System which permits determination of mutagen-induced chromosome aberration, and sister chromatid exchange (SCE) in
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