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343536

1-Boc-哌嗪

Name: 1-Boc-哌嗪
Brand: ALDRICH

97%

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别名:

哌嗪-1-甲酸叔丁酯

经验公式（希尔记法）:

C₉H₁₈N₂O₂

CAS号:

57260-71-6

分子量:

186.25

Beilstein:

879985

MDL编号:

MFCD00075265

PubChem化学物质编号:

24861171

NACRES:

NA.22

质量水平

200

检测方案

97%

形式

solid

mp

43-47 °C (lit.)

SMILES字符串

CC(C)(C)OC(=O)N1CCNCC1

InChI

1S/C9H18N2O2/c1-9(2,3)13-8(12)11-6-4-10-5-7-11/h10H,4-7H2,1-3H3

InChI key

CWXPZXBSDSIRCS-UHFFFAOYSA-N

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一般描述

1-Boc-哌嗪是-Boc保护的哌嗪。1-Boc-哌嗪与芳基碘的CuBr/1，1′交叉偶联。研究报道了铋-2-萘酚（催化剂）和K₃PO₄（碱）。1-Boc-哌嗪与芳基卤化物发生布赫华-哈特威格偶联反应。碘催化无溶剂N-Boc保护可制备80%产率的1-Boc-哌嗪。

应用

1-Boc-哌嗪可用于：

（m·-苯氧基）苯基取代哌嗪衍生物系列的制备
通过活性阳离子开环聚合合成α,β-聚（2-噁唑啉）脂聚合物期间的终止步骤。
单取代哌嗪的制备，例如吲唑脱氧核糖核酸回旋酶抑制剂的合成

象形图

GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

预防措施声明

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

235.4 °F - closed cup

闪点(°C)

113 °C - closed cup

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

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MMYOMAG-74K-13

1000309185

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Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity.

Akihiko Tanitame et al.

Bioorganic & medicinal chemistry letters, 14(11), 2857-2862 (2004-05-06)

In this study, we report the design, synthesis and structure-activity relationships of novel indazole derivatives as DNA gyrase inhibitors with Gram-positive antibacterial activity. Our results show that selected compounds from this series exhibit potent antibacterial activity against Gram-positive bacteria including

1-alkyl-4-acylpiperazines as a new class of imidazole-free histamine H(3) receptor antagonists.

Florencio Zaragoza et al.

Journal of medicinal chemistry, 47(11), 2833-2838 (2004-05-14)

With the aim of identifying structurally novel, centrally acting histamine H(3) antagonists, arrays of monoacyldiamines were screened. This led to the discovery of a series of 1-alkyl-4-acylpiperazines which were potent antagonists at the human histamine H(3) receptor. The most potent

α,ω-Functionalized Poly (2-Oxazoline) s Bearing Hydroxyl and Amino Functions.

Reif M and Jordan R.

Macromolecular Chemistry and Physics, 212(16), 1815-1824 (2011)

Molecular iodine-catalyzed facile procedure for N-Boc protection of amines.

Ravi Varala et al.

The Journal of organic chemistry, 71(21), 8283-8286 (2006-10-10)

An efficient and practical protocol for the protection of various structurally and electronically divergent aryl and aliphatic amines using (Boc)2O in the presence of a catalytic amount of molecular iodine (10 mol %) under solvent-free conditions at ambient temperature is

Synthesis and dual D2 and 5-HT1A receptor binding affinities of 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones.

Nisar Ullah

Journal of enzyme inhibition and medicinal chemistry, 29(2), 281-291 (2013-03-16)

A series of new 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones have been synthesized and evaluated for dual D2 and 5-HT1A receptor binding affinities. The synthesized ligands are structurally related to bifeprunox, a potential atypical antipsychotic, having potent D2 receptor antagonist and 5-HT1A receptor

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