349631
2-酮戊二酸二甲酯
96%
别名:
α-酮戊二酸二甲酯
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关于此项目
线性分子式:
CH3O2CCH2CH2COCO2CH3
CAS Number:
分子量:
174.15
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
质量水平
方案
96%
表单
liquid
折射率
n20/D 1.439 (lit.)
沸点
90-95 °C/0.4 mmHg (lit.)
密度
1.203 g/mL at 25 °C (lit.)
官能团
ester
ketone
SMILES字符串
COC(=O)CCC(=O)C(=O)OC
InChI
1S/C7H10O5/c1-11-6(9)4-3-5(8)7(10)12-2/h3-4H2,1-2H3
InChI key
TXIXSLPEABAEHP-UHFFFAOYSA-N
一般描述
2-氧戊二酸二甲酯是在Krebs循环期间形成的关键中间体，并且是生物代谢途径中的重要氮转运子。2-氧戊二酸二甲酯的电化学行为已通过循环伏安法、方波伏安法和使用玻碳电极的差分脉冲伏安法进行了研究。
应用
2-氧代戊二酸二甲酯可以与双亲核物，如1,2-苯二胺、2-氨基苯酚和2-氨基苯硫醇，进行环缩合以形成新的杂环。
2-氧戊二酸二甲酯可用于合成构象受限的PNA（肽核酸）单体，该单体能够在三重基序中结合胸腺嘧啶。它可以通过与硝基苯乙烯的高度立体选择性Michael加成反应,合成4-芳基红藻氨酸类似物。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves
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Afzal Shah et al.
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Nicholas Jones et al.
Nature communications, 10(1), 2042-2042 (2019-05-06)
Metabolic pathways that regulate T-cell function show promise as therapeutic targets in diverse diseases. Here, we show that at rest cultured human effector memory and central memory CD4+ T-cells have elevated levels of glycolysis and oxidative phosphorylation (OXPHOS), in comparison
An efficient synthesis of 4-aryl kainic acid analogs.
Maeda H, et al.
Tetrahedron, 55(4), 943-954 (1999)
商品
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Sigma article discusses tumor cell metabolic pathways, focusing on aerobic glycolysis and mitochondrial activity.
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