349720
(3-羧丙基)三苯基溴化膦
98%
别名:
(4-羟基-4-氧代丁基)三苯基溴化膦
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关于此项目
线性分子式:
HO2C(CH2)3P(C6H5)3Br
化学文摘社编号:
分子量:
429.29
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352002
MDL number:
产品名称
(3-羧丙基)三苯基溴化膦, 98%
InChI
1S/C22H21O2P.BrH/c23-22(24)17-10-18-25(19-11-4-1-5-12-19,20-13-6-2-7-14-20)21-15-8-3-9-16-21;/h1-9,11-16H,10,17-18H2;1H
SMILES string
[Br-].OC(=O)CCC[P+](c1ccccc1)(c2ccccc2)c3ccccc3
InChI key
NKVJKVMGJABKHV-UHFFFAOYSA-N
assay
98%
reaction suitability
reaction type: C-C Bond Formation
mp
244-247 °C (lit.)
functional group
carboxylic acid
phosphine
Quality Level
Application
用作制备以下物质的反应物：
- 哌啶类似物，作为具有抗肿瘤活性的组蛋白脱乙酰基酶（HDAC）抑制剂
- 含硼的苯并氧杂硼烷类化合物，作为抗疟药
- 甲基烯基喹诺酮类化合物，作为抗分枝杆菌剂
- 依次经过Sharpless环氧化反应、Taber环丙烷化反应、化学选择性还原反应和锂化-硼化-烯丙基化反应，合成Solandelactone E
- 有机锡化合物，作为抗真菌剂
- 齐墩果酸衍生物作为蛋白酪氨酸磷酸酶1B的抑制剂，可抑制胰岛素途径（糖尿病和肥胖症治疗的有前景的靶标）
- 11-oxa前列腺素类似物，具有降眼压活性
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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