Merck
CN
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文件

349720

Sigma-Aldrich

(3-羧丙基)三苯基溴化膦

98%

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别名:
(4-羟基-4-氧代丁基)三苯基溴化膦
线性分子式:
HO2C(CH2)3P(C6H5)3Br
CAS号:
17857-14-6
分子量:
429.29
MDL编号:
MFCD00274196
PubChem化学物质编号:
24861704
NACRES:
NA.22

质量水平

100

检测方案

98%

reaction suitability

reaction type: C-C Bond Formation

mp

244-247 °C (lit.)

SMILES string

[Br-].OC(=O)CCC[P+](c1ccccc1)(c2ccccc2)c3ccccc3

InChI

1S/C22H21O2P.BrH/c23-22(24)17-10-18-25(19-11-4-1-5-12-19,20-13-6-2-7-14-20)21-15-8-3-9-16-21;/h1-9,11-16H,10,17-18H2;1H

InChI key

NKVJKVMGJABKHV-UHFFFAOYSA-N

相关类别

应用

用作制备以下物质的反应物：
  • 哌啶类似物，作为具有抗肿瘤活性的组蛋白脱乙酰基酶（HDAC）抑制剂
  • 含硼的苯并氧杂硼烷类化合物，作为抗疟药
  • 甲基烯基喹诺酮类化合物，作为抗分枝杆菌剂
  • 依次经过Sharpless环氧化反应、Taber环丙烷化反应、化学选择性还原反应和锂化-硼化-烯丙基化反应，合成Solandelactone E
  • 有机锡化合物，作为抗真菌剂
  • 齐墩果酸衍生物作为蛋白酪氨酸磷酸酶1B的抑制剂，可抑制胰岛素途径（糖尿病和肥胖症治疗的有前景的靶标）
  • 11-oxa前列腺素类似物，具有降眼压活性

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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