质量水平
方案
97%
表单
liquid
沸点
142 °C/15 mmHg (lit.)
mp
13 °C (lit.)
密度
1.14 g/mL at 25 °C (lit.)
SMILES字符串
c1ccc(cc1)-n2ccnc2
InChI
1S/C9H8N2/c1-2-4-9(5-3-1)11-7-6-10-8-11/h1-8H
InChI key
SEULWJSKCVACTH-UHFFFAOYSA-N
一般描述
1-苯基咪唑是咪唑衍生物。它在虹鳟鱼（虹鳟鱼）肝细胞中诱导 7-乙氧基试卤灵-O-脱乙基酶（EROD）活化。1-苯咪唑的 S（1）→S（0）跃迁已通过共振双光子电离在超声气流膨胀中进行了研究。据报道，1-苯基咪唑是牛脑和 Ghs 垂体细胞钙调蛋白依赖性一氧化氮合酶的抑制剂。
应用
1-苯基咪唑是一种研究其对牛脑一氧化氮合酶对瓜氨酸形成的影响的合适试剂。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
235.4 °F - closed cup
闪点(°C)
113 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Filippo Monti et al.
Inorganic chemistry, 54(6), 3031-3042 (2015-03-06)
A series of cationic iridium(III) complexes with two carbene-based cyclometalating ligands and five different N^N bipyridine and 1,10-phenanthroline ancillary ligands is presented. For the first time--in the frame of a rarely studied class of bis(heteroleptic) iridium complexes with two carbene-based
M Murray et al.
Toxicology letters, 25(2), 191-198 (1985-05-01)
Repeated administration of N-phenylimidazole (PI) to rats (3 daily doses of 200 mumol/kg/day) enhanced hepatic microsomal cytochrome P-450 levels (approx. 130%) and aminopyrine N-demethylase (APDM) and aniline p-hydroxylase (APH) activities (approx. 140%); aryl hydrocarbon (benzo[a]pyrene) hydroxylase (AHH) and 7-ethoxycoumarin O-deethylase
A J Green et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 6(5-6), 523-533 (2001-07-27)
The bioI gene has been sub-cloned and over-expressed in Escherichia coli, and the protein purified to homogeneity. The protein is a cytochrome P450, as indicated by its visible spectrum (low-spin haem iron Soret band at 419 nm) and by the
A Jos et al.
Toxicology in vitro : an international journal published in association with BIBRA, 21(7), 1307-1310 (2007-05-25)
The classical pathway for induction of cytochrome P4501A (CYP1A) by xenobiotics is ligand binding to the aryl hydrocarbon receptor (AhR). However, several studies with mammalian cell systems point out a range of xenobiotics including imidazole derivatives, which are able to
M R Anari et al.
Chemical research in toxicology, 9(6), 924-931 (1996-09-01)
Organic hydroperoxides are believed to be primarily detoxified in cells by the GSH peroxidase/GSSG reductase system and activated to cytotoxic radical species by non-heme iron. However, organic hydroperoxides seem to be bioactivated by cytochrome P450 (P450) in isolated hepatocytes as
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