1,5,6,7-四氢-4H-吲哚-4-酮

Name: 1,5,6,7-四氢-4<I>H</I>-吲哚-4-酮
Brand: ALDRICH

98%

别名:

4,5,6,7-Tetrahydro-4-oxoindole, NSC 131681

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₈H₉NO

CAS Number:

13754-86-4

分子量:

135.16

MDL编号:

MFCD00075438

UNSPSC代码:

12352100

PubChem化学物质编号:

24861947

NACRES:

NA.22

质量水平

100

方案

98%

mp

188-190 °C (lit.)

官能团

ketone

SMILES字符串

O=C1CCCc2[nH]ccc12

InChI

1S/C8H9NO/c10-8-3-1-2-7-6(8)4-5-9-7/h4-5,9H,1-3H2

InChI key

KASJZXHXXNEULX-UHFFFAOYSA-N

一般描述

Iodination of 1,5,6,7-tetrahydro-4H-indol-4-one using 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) yields α-iodo derivative as the main product.

应用

1,5,6,7-Tetrahydro-4H-indol-4-one may be used in the preparation of:

4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carbonitrile
methyl 2-(4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)acrylate
3-(4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)propanenitrile
potent and orally active 5-HT1A agonists, (R)-(+)- and (S)-(-)-1-formyl-6,7,8,9-tetrahydro-N,N-dipropyl-3H-benz[e]indol-8-amines

Reactant in synthesis of psammopemmin A as antitumor agent
Reactant in synthesis of a 1,3,4,5-tetrahydrobenzindole β-ketoesters and tricyclic tetrahydrobenzindoles via C-H insertion reactions
Reactant in preparation of tricyclic indole and dihydroindole derivatives as inhibitors of guanylate cyclase
Reactant in preparation of condensed pyrroloindoles via Pd-catalyzed intramolecular C-H bond functionalization of (halobenzyl)pyrroles
Reactant in enantioselective preparation of arylalkenyl indoles via asymmetric C-H insertion of rhodium carbenoids followed by Cope rearrangement-elimination