361275
3′-脱氧-3′-氟胸苷
97%
别名:
3′-Fluoro-2′,3′-dideoxythymidine, 3′-Fluorodeoxythymidine
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关于此项目
经验公式（希尔记法）:
C10H13FN2O4
化学文摘社编号:
分子量:
244.22
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
产品名称
3′-脱氧-3′-氟胸苷, 97%
InChI
1S/C10H13FN2O4/c1-5-3-13(10(16)12-9(5)15)8-2-6(11)7(4-14)17-8/h3,6-8,14H,2,4H2,1H3,(H,12,15,16)/t6-,7+,8+/m0/s1
SMILES string
CC1=CN([C@H]2C[C@H](F)[C@@H](CO)O2)C(=O)NC1=O
InChI key
UXCAQJAQSWSNPQ-XLPZGREQSA-N
assay
97%
form
solid
mp
176-178 °C (lit.)
storage temp.
2-8°C
Quality Level
Gene Information
human ... TK2(7084)
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Application
具有应用前景的抗病毒试剂，活性类似于其他 3′-脱氧-3′-取代胸苷。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Julian L Goggi et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(9), 1630-1636 (2013-08-03)
Successful antiangiogenic therapies have been developed for the treatment of various cancers, but not all patients respond. Therefore, the early determination of therapy efficacy is essential for patient management. This study was done to evaluate the utility of various PET
P Herdewijn et al.
Journal of medicinal chemistry, 30(8), 1270-1278 (1987-08-01)
A series of 2',3'-unsaturated and 3'-substituted 2',3'-dideoxynucleoside analogues of purines and pyrimidines have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV). The 2',3'-unsaturated analogues of 2',3'-dideoxycytidine (ddeCyd) and 2',3'-dideoxythymidine (ddeThd), 3'-azido-2',3'-dideoxythymidine (AzddThd), 3'-fluoro-2',3'-dideoxythymidine, 2',3'-dideoxycytidine (ddCyd)
Bianca A W Hoeben et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(4), 532-540 (2013-01-25)
This prospective study used sequential PET with the proliferation tracer 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) to monitor the early response to treatment of head and neck cancer and evaluated the association between PET parameters and clinical outcome. Forty-eight patients with head and neck
Camilo Garcia et al.
Current opinion in oncology, 24(6), 748-755 (2012-08-24)
(18)F-fluoro-2-deoxy-D-glucose PET-computed tomography (CT) has a major clinical impact in oncology not only for diagnostics but also for staging, response assessment, and relapse detection. However, several other PET tracers are needed for a more complete molecular characterization of cancers which
Michael S Enslow et al.
Clinical nuclear medicine, 37(9), 854-861 (2012-08-15)
The objective was to compare F-fluorodeoxyglucose (FDG) and F-fluorothymidine (FLT) PET in differentiating radiation necrosis from recurrent glioma. Visual and quantitative analyses were derived from static FDG PET and static and dynamic FLT PET in 15 patients with suspected recurrence
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