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363057

6-O-甲基鸟嘌呤

Name: 6-<I>O</I>-甲基鸟嘌呤
Brand: ALDRICH

97%

别名:

2-氨基-6-甲氧基嘌呤, 6-甲氧基鸟嘌呤

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关于此项目

经验公式（希尔记法）:

C₆H₇N₅O

化学文摘社编号:

20535-83-5

分子量:

165.15

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24862349

MDL number:

MFCD00133009

Beilstein/REAXYS Number:

645384

Assay:

97%

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属性

Quality Level

200

assay

97%

mp

>300 °C (lit.)

SMILES string

COc1nc(N)nc2[nH]cnc12

InChI

1S/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)

InChI key

BXJHWYVXLGLDMZ-UHFFFAOYSA-N

Gene Information

human ... CDK2(1017), MGMT(4255)

说明

General description

6-O-甲基鸟嘌呤是一种嘌呤衍生物，它的结合亲和力已通过使用等温滴定热法（ITC）利用枯草芽孢杆菌xpt-pbuX鸟嘌呤核糖开关（GR）进行了检查。6-O-甲基鸟嘌呤是在一系列纯化的tRNA制剂的烷基化过程中通过与致癌物N-甲基-N-亚硝基脲反应而形成的。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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DNA damaging agents are potent inducers of cell death triggered by apoptosis. Since these agents induce a plethora of different DNA lesions, it is firstly important to identify the specific lesions responsible for initiating apoptosis before the apoptotic executing pathways

Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage.

Anna V Knizhnik et al.

PloS one, 8(1), e55665-e55665 (2013-02-06)

Apoptosis, autophagy, necrosis and cellular senescence are key responses of cells that were exposed to genotoxicants. The types of DNA damage triggering these responses and their interrelationship are largely unknown. Here we studied these responses in glioma cells treated with

Adaptive ligand binding by the purine riboswitch in the recognition of guanine and adenine analogs.

Sunny D Gilbert et al.

Structure (London, England : 1993), 17(6), 857-868 (2009-06-16)

Purine riboswitches discriminate between guanine and adenine by at least 10,000-fold based on the identity of a single pyrimidine (Y74) that forms a Watson-Crick base pair with the ligand. To understand how this high degree of specificity for closely related

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货号	GTIN
363057-500MG	04061833472989