363340
N-乙酰基半胱胺
95%
别名:
N-(2-Mercaptoethyl)acetamide
方案
95%
表单
liquid
折射率
n20/D 1.511 (lit.)
沸点
138-140 °C/7 mmHg (lit.)
mp
6-7 °C (lit.)
密度
1.121 g/mL at 25 °C (lit.)
官能团
amide
thiol
SMILES字符串
CC(=O)NCCS
InChI
1S/C4H9NOS/c1-4(6)5-2-3-7/h7H,2-3H2,1H3,(H,5,6)
InChI key
AXFZADXWLMXITO-UHFFFAOYSA-N
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一般描述
N-乙酰基半胱胺，又称N-(2-巯基乙基)乙酰胺，是半胱胺的衍生物，常用作合成砌块经由酯化反应合成烷基硫醇类与硫酯类。
应用
N-乙酰半胱氨酸可作为结构单元用于合成：
- N
- -乙酰半胱胺（SNAC）硫酯，通过在1,1′-羰二咪唑（CDI）参与下与多种酸衍生物反应。
- 噻吩并[2,3-c]吡咯衍生物,通过2-乙酰基-3-噻吩甲醛和各种胺的三组分反应。
- 碳青霉烯是一类beta-内酰胺类抗生素。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
235.4 °F - closed cup
闪点(°C)
113 °C - closed cup
个人防护装备
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Tetrahedron Letters, 29, 4305-4305 (1988)
Thomas Frenzel et al.
Organic letters, 8(1), 135-138 (2005-12-31)
[structure: see text] The enantioselective total synthesis of the N-acetylcysteamine thioester of seco-proansamitocin, a key biosynthetic intermediate of the highly potent antitumor agent ansamitocin, is described, which twice utilizes the Nagao acetate aldol reaction, as well as an indium-mediated alkynylation
S A Moore et al.
The Journal of biological chemistry, 257(18), 10874-10881 (1982-09-25)
Succinyl phosphate reacts rapidly with the thiol N-acetyl-beta-mercaptoethylamine (a CoA analog) to form the succinate thiol ester. This is a chemical model for the enzymic reaction of CoA transferase. It is demonstrated that: 1) the chemical reaction is stepwise, proceeding
Ewa Maria Musiol-Kroll et al.
Antibiotics (Basel, Switzerland), 7(3) (2018-07-20)
Polyketides belong to the most valuable natural products, including diverse bioactive compounds, such as antibiotics, anticancer drugs, antifungal agents, immunosuppressants and others. Their structures are assembled by polyketide synthases (PKSs). Modular PKSs are composed of modules, which involve sets of
Journal of the Chemical Society. Perkin Transactions 1, 2345-2345 (1988)
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