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文件

373974

Sigma-Aldrich

聚（2-乙基-2-恶唑啉）

average Mw ~500,000, PDI 3‑4

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别名:
PEOX, POx, PetOx, 聚 2-乙基恶唑啉, 聚乙氧基唑啉
线性分子式:
[-N(COC2H5)CH2CH2-]n
CAS号:
25805-17-8
MDL编号:
MFCD00134377
PubChem化学物质编号:
329755641
NACRES:
NA.23

形式

solid

分子量

average Mw ~500,000

粘度

60-80 cSt, 10 % in H2O

密度

1.14 g/mL at 25 °C (lit.)

PDI

3‑4

InChI

1S/C5H9NO/c1-2-5-6-3-4-7-5/h2-4H2,1H3

InChI key

NYEZZYQZRQDLEH-UHFFFAOYSA-N

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应用

这种聚（2-乙基-2-恶唑啉）聚合物是无定形和水溶性的，具有良好的温度稳定性。Jordan 及其同事证明了生物相容性，其在组织中无蓄积，并从血流中快速清除 。末端基团修饰的聚（2-乙基-2-恶唑啉）已与肽偶联 ，并被证明可以替代聚乙二醇 (PEG) 用于蛋白质和小分子药物的偶联 。

聚（乙烯醇）和聚（乙烯基吡咯烷酮）的潜在替代品。涂料中的粘合促进剂。热封和可再湿润的热熔胶

特点和优势

非离子型水溶性热塑性塑料。具有比聚乙烯醇更优越的热稳定性。具有良好的熔体流动性、剪切稳定性和牛顿特性。水是室温 θ 溶剂。

外形

N-丙酰基取代线性聚乙烯亚胺

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Issa Katime et al.
Applied spectroscopy, 57(7), 829-834 (2003-12-09)
This paper reports an FT-IR study of blends of poly(mono-n-alkyl itaconates) with poly(N,N-dimethylacrylamide) (PDMA) and poly(ethyloxazoline) (PEOX). Strong hydrogen bonding has been found, and both polybases have shown similar acceptor strengths. Derivative techniques show asymmetric profiles for the free carbonyl
J H Jeong et al.
Journal of controlled release : official journal of the Controlled Release Society, 73(2-3), 391-399 (2001-08-23)
A series of linear poly(ethylenimine) (L-PEI) containing varying amounts of cationic charge density in its backbone was produced by controlled hydrolysis of poly(2-ethyl-2-oxazoline) (PEtOz) for using as a nonviral DNA transfection agent. The effects of cationic charge density and molecular
I C Kwon et al.
Nature, 354(6351), 291-293 (1991-11-28)
New controlled drug-delivery systems are being explored to overcome the disadvantages of conventional dosage forms. For example, stimulated drug-delivery has been used to overcome the tolerance problems that occur with a constant delivery rate, to mimic the physiological pattern of
Yung-Chu Chen et al.
Journal of biomedical materials research. Part A, 100(5), 1279-1292 (2012-03-01)
The multifunctional nanoparticles constructed from triphenylamine-poly(lactide-co-glycolide)-poly(ethyleneglycol)-poly(lactide-co-glycolide) (TPA-PEP) and folate-poly(2-ethyl-2oxazoline)-poly(D,L-lactide) (folate-PEOz-PLA) were developed in this study. Iron oxide nanoparticles (IOP) and paclitaxel (PTX) were coencapsulated in the nanoparticles with diameter less than 200 nm. The drug-loaded nanoparticles emit fluorescence peak at
Chau-Hui Wang et al.
Journal of controlled release : official journal of the Controlled Release Society, 108(1), 140-149 (2005-09-27)
Polymeric micelles based on poly(L-lactide)-b-poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) (PLLA-PEOz-PLLA) ABA triblock copolymers were designed as intracellular drug carriers. The PLLA-PEOz-PLLA micelles adopt a "flower-like" arrangement with A-blocks at the core and a B-block on the shell under neutral condition. The deformation of the
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