CN
所有图片(2)
别名:
2,4(3H,5H)-Thiazoledione, 2,4-Dioxo-1,3-thiazolidine, 2,4-Dioxothiazolidine, 2-Hydroxy-4,5-dihydro-1,3-thiazol-4-one, Thiazole-2,4-dione, Thiazolidin-2,4-dione, Thiazolidinedione (6CI)
经验公式（希尔记法）:
C3H3NO2S
CAS号:
分子量:
117.13
Beilstein:
110700
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22
等级
technical grade
质量水平
检测方案
90%
mp
125-127 °C (lit.)
SMILES字符串
O=C1CSC(=O)N1
InChI
1S/C3H3NO2S/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
InChI key
ZOBPZXTWZATXDG-UHFFFAOYSA-N
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一般描述
2,4-噻唑烷二酮是一种著名的过氧化物酶体增殖物激活受体（PPAR）激活剂。它对衰老过程的影响通过使用来自Fischer 344大鼠的肾脏已被报道。2,4-噻唑烷二酮的耦合物文库已通过Knoevenagel缩合以及后续使用氢气和Pd/C催化剂的还原反应而合成得到。已经报道了各种芳香醛与聚乙二醇-300中的2,4-噻唑烷二酮的Knoevenagel缩合。
应用
2,4-噻唑烷二酮可通过超声促进的羟醛缩合反应用于十六个5-亚芳基-2,4-噻唑烷二酮的合成。它可作为起始材料用于合成具有抗高血糖活性的药物。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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K M Schoenberg et al.
Journal of dairy science, 94(11), 5523-5532 (2011-10-29)
Administration of peroxisome proliferator-activated receptor gamma (PPARγ) ligands, thiazolidinediones (TZD), to prepartum dairy cattle has been shown to improve dry matter intake and decrease circulating nonesterified fatty acids (NEFA) around the time of calving. The objective of this work was
Jaelim Cho et al.
Clinical pharmacology and therapeutics, 107(3), 580-587 (2019-09-26)
Acute pancreatitis (AP) often progresses to recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP). We investigated the relationship between the use of insulin after AP and progression from AP to RAP or CP, as well as the effect of diabetes
Shana Jaaf et al.
Veterinary sciences, 6(2) (2019-05-22)
Background: In a prior experiment, treatment of goats with the putative PPARγ agonist 2,4-thiazolidinedione (2,4-TZD) did not affect milk fat or expression of milk-fat related genes. The lack of response was possibly due to deficiency of vitamin A and/or a
Suzanne V Arnold et al.
Circulation. Heart failure, 12(6), e005855-e005855 (2019-05-28)
Background Thiazolidinediones (rosiglitazone, pioglitazone) are oral insulin-sensitizing medications used in type 2 diabetes mellitus that reduce glucose with minimal risk of hypoglycemia and potential benefits on atherosclerosis. However, thiazolidinediones can cause fluid retention thereby increasing the risk of heart failure-a
A Koch et al.
British journal of pharmacology, 166(3), 1018-1032 (2012-01-10)
PPARγ agonists [thiazolidinediones (TZDs)] are known to exert anti-fibrotic effects in the kidney. In addition, we previously demonstrated that sphingosine kinase 1 (SK-1) and intracellular sphingosine-1-phosphate (S1P), by reducing the expression of connective tissue growth factor (CTGF), have a protective
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