375004
2,4-噻唑烷二酮
technical grade, 90%
别名:
2,4(3H,5H)-噻唑二酮, 2,4-二氧代-1,3-噻唑烷, 2,4-二氧代噻唑烷, 2-羟基-4,5-二氢-1,3-噻唑-4-酮, 噻唑-2,4-二酮, 噻唑啉-2,4-二酮, 噻唑烷二酮 (6CI)
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关于此项目
经验公式（希尔记法）:
C3H3NO2S
化学文摘社编号:
分子量:
117.13
Beilstein:
110700
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
等级
technical grade
质量水平
方案
90%
mp
125-127 °C (lit.)
SMILES字符串
O=C1CSC(=O)N1
InChI
1S/C3H3NO2S/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
InChI key
ZOBPZXTWZATXDG-UHFFFAOYSA-N
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一般描述
2,4-噻唑烷二酮是一种著名的过氧化物酶体增殖物激活受体（PPAR）激活剂。它对衰老过程的影响通过使用来自Fischer 344大鼠的肾脏已被报道。2,4-噻唑烷二酮的耦合物文库已通过Knoevenagel缩合以及后续使用氢气和Pd/C催化剂的还原反应而合成得到。已经报道了各种芳香醛与聚乙二醇-300中的2,4-噻唑烷二酮的Knoevenagel缩合。
应用
2,4-噻唑烷二酮可通过超声促进的羟醛缩合反应用于十六个5-亚芳基-2,4-噻唑烷二酮的合成。它可作为起始材料用于合成具有抗高血糖活性的药物。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Tien-Jyun Chang et al.
Pharmacogenetics and genomics, 21(12), 829-836 (2011-09-22)
This study aimed to analyze the association of thiazolidinedione (TZD)-related edema with genetic and clinical variables and develop a simple points system to predict the risk of developing TZD-related edema. Fifty-eight (21.6%) of 268 individuals who received TZD for type
Suzanne V Arnold et al.
Circulation. Heart failure, 12(6), e005855-e005855 (2019-05-28)
Background Thiazolidinediones (rosiglitazone, pioglitazone) are oral insulin-sensitizing medications used in type 2 diabetes mellitus that reduce glucose with minimal risk of hypoglycemia and potential benefits on atherosclerosis. However, thiazolidinediones can cause fluid retention thereby increasing the risk of heart failure-a
A Koch et al.
British journal of pharmacology, 166(3), 1018-1032 (2012-01-10)
PPARγ agonists [thiazolidinediones (TZDs)] are known to exert anti-fibrotic effects in the kidney. In addition, we previously demonstrated that sphingosine kinase 1 (SK-1) and intracellular sphingosine-1-phosphate (S1P), by reducing the expression of connective tissue growth factor (CTGF), have a protective
Sabrina Heng et al.
Bioorganic & medicinal chemistry, 19(24), 7453-7463 (2011-11-15)
We present a new class of inhibitors of pancreatic cholesterol esterase (CEase) based on 'priviledged' 5-benzylidenerhodanine and 5-benzylidene-2,4-thiazolidinedione structural scaffolds. The lead structures (5-benzylidenerhodanine 4a and 5-benzylidene-2,4-thiazolidinedione 4b) were identified in an in-house screening and these inhibited CEase with some
A Zask et al.
Journal of medicinal chemistry, 33(5), 1418-1423 (1990-05-01)
A series of 5-(naphthalenylsulfonyl)-2,4-thiazolidinediones were synthesized and evaluated for antihyperglycemic activity in an insulin-resistant, genetically diabetic db/db mouse model of non-insulin-dependent diabetes mellitus (NIDDM). The sulfones could be synthesized by a novel, selective C-5 sulfonylation of dilithio-2,4-thiazolidinedione with appropriate sulfonyl
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