391913
(R)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸
98%
别名:
(2R)-3,4-二氢-6-羟基-2,5,7,8-四甲基-2H-1-苯并吡喃-2-甲酸, (R)-Trolox
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关于此项目
经验公式（希尔记法）:
C14H18O4
化学文摘社编号:
分子量:
250.29
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
Assay:
98%
Form:
solid
InChI
1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)/t14-/m1/s1
SMILES string
Cc1c(C)c2O[C@](C)(CCc2c(C)c1O)C(O)=O
InChI key
GLEVLJDDWXEYCO-CQSZACIVSA-N
assay
98%
form
solid
optical activity
[α]27/D +65°, c = 1.2 in ethanol
mp
162 °C (dec.) (lit.)
functional group
carboxylic acid
Quality Level
General description
( R )-(+)-6-羟基-2，5，7，8-四甲基色-2-羧酸，为维生素 E 类似物，是一种蘑菇酪氨酸酶抑制剂。
Application
当设计基于γ-氨基丁酸（GABA）的抗应激剂时。（R） - （+） - 6-羟基-2,5,7,8-四甲基色满-2-羧酸可用于结合抗氧化性能。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Acta poloniae pharmaceutica, 74(2), 670-678 (2018-04-07)
Polyphenol rich extracts obtained from cistus herb (Cistus incanus L.) and pomegranate peels (Punica granatunm L.) added at high concentrations (25-100 pg/mL) to V79 (Chinese hamster lung fibroblast) cell cultures, markedly increased intracellular level of ROS (reactive oxygen species). Also
Helena Moreira et al.
Acta poloniae pharmaceutica, 74(2), 688-698 (2018-04-07)
Polyphenol rich extracts obtained from cistus herb (Cistus incanus L.) and pomegranate peel (Punica granatum L.) exhibited significant antioxidant activity in V79 cell culture (Chinese hamster lung fibroblasts) -cistus extract reduced intracellular content of reactive oxygen species (ROS) by 30-40%
Novel compounds designed as antistress agents.
Tsiakitzis, KC, et al.
Journal of Medicinal Chemistry, 52(22), 7315-7318 (2009)
Shyamal Subramanyam et al.
Methods in enzymology, 600, 201-232 (2018-02-21)
Human RAD51 promotes accurate DNA repair by homologous recombination and is involved in protection and repair of damaged DNA replication forks. The active species of RAD51 and related recombinases in all organisms is a nucleoprotein filament assembled on single-stranded DNA
Inhibitory effects of (S)-and (R)-6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acids on tyrosinase activity.
Yu L.
Journal of Agricultural and Food Chemistry, 51(8), 2344-2347 (2003)
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