3,5-二甲基-1-碘苯

Name: 3,5-二甲基-1-碘苯
Brand: ALDRICH

99%

别名:

5-碘间二甲苯

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所有图片(1)

About This Item

线性分子式:

(CH₃)₂C₆H₃I

CAS Number:

22445-41-6

分子量:

232.06

MDL编号:

MFCD00060659

UNSPSC代码:

12352100

PubChem化学物质编号:

24864461

NACRES:

NA.22

质量水平

100

方案

99%

表单

liquid

折射率

n20/D 1.594 (lit.)

沸点

92-94 °C/3 mmHg (lit.)

密度

1.608 g/mL at 25 °C (lit.)

官能团

iodo

SMILES字符串

Cc1cc(C)cc(I)c1

InChI

1S/C8H9I/c1-6-3-7(2)5-8(9)4-6/h3-5H,1-2H3

InChI key

ZLMKEENUYIUKKC-UHFFFAOYSA-N

一般描述

1-Iodo-3,5-dimethylbenzene (5-Iodo-m-xylene) is an aryl halide. It can be obtained from 5-bromo-m-xylene, via copper-catalyzed halogen exchange reaction, in the presence of NaI or KI in n-BuOH or DMF (solvents). It undergoes reaction with phenol in the presence of CuFe₂O₄nano powder as a recyclable catalyst to afford 1,3-dimethyl-5-phenoxybenzene.

应用

1-Iodo-3,5-dimethylbenzene (5-iodo-m-xylene) is suitable for use in the synthesis of N-(3,5-xylyl)-N-ethylaniline, an arylamine.
It may be used in the following studies:

α-Arylation of ketones.
Copper-catalyzed N-arylation of imidazoles.
Cyanation of 5-iodo-m-xylene to form 3,5-dimethylbenzonitrile.
Synthesis of 1,3-Dimethyl-5-phenoxybenzene by nano-CuFe₂O₄ catalyzed C-O cross-coupling with phenol.
CuBr-catalyzed amination of 1-iodo-3,5-dimethylbenzene to form N-Allyl-3,5-dimethylbenzenamine.
Copper-catalyzed C-S bond-formation between 5-iodo-m-xylene and thiophenol.
As a starting material in the synthesis of biphenyl-3,3′,5,5′-tetracarboxylic acid.
Radical bromination of 5-iodo-m-xylene by N-bromosuccinimide to form 1,3-bis(bromomethyl)-5-iodobenzene.