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Merck
CN

39915

七(2,6-二-O-甲基)-β-环糊精

≥98.0% (TLC)

别名:

2,6-二-O-甲基-β-环糊精, 二甲基 β-环糊精

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关于此项目

经验公式（希尔记法）:
C56H98O35
化学文摘社编号:
51166-71-3
分子量:
1331.36
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
57649911
MDL number:
MFCD00011616
Beilstein/REAXYS Number:
1679144

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产品名称

七(2,6-二-O-甲基)-β-环糊精, ≥98.0% (TLC)

InChI

1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3/t22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-/m1/s1

SMILES string

COC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](OC)[C@H](O[C@@H]3COC)O[C@H]4[C@H](O)[C@@H](OC)[C@H](O[C@@H]4COC)O[C@H]5[C@H](O)[C@@H](OC)[C@H](O[C@@H]5COC)O[C@H]6[C@H](O)[C@@H](OC)[C@H](O[C@@H]6COC)O[C@H]7[C@H](O)[C@@H](OC)[C@H](O[C@@H]7COC)O[C@H]8[C@H](O)[C@@H](OC)[C@H](O[C@@H]8COC)O[C@H]1[C@H](O)[C@H]2OC

InChI key

QGKBSGBYSPTPKJ-UZMKXNTCSA-N

assay

≥98.0% (TLC)

optical activity

[α]20/D +158±3°, c = 10% in H2O

impurities

≤3% water

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Application

涉及的反应物：
  • 包合物的理化研究
  • 与重组膜蛋白的探测扩散和单分子相互作用
  • 与胶束的相互作用导致胶束破裂
  • 研究细胞转运，用作细胞渗透促进剂
  • 药物的理化和生物药剂学改进 ，特别是溶解和稳定性
  • 与胆固醇的相互作用
Heptakis(2,6-di-O-methyl)-β-cyclodextrin may be used:
  • To measure the equilibrium constant of its complexes with various enantiomeric pairs of chiral nitroxides by electron paramagnetic resonance (EPR) spectroscopy.
  • To study the crystal structure of its complex with n-butyl acrylate and isobornyl acrylate using X-ray diffraction (XRD).
  • As a chiral selector to resolve amphetamine related drugs and reduced haloperidol by capillary zone electrophoresis.
  • As a component of thermosensitive polyurethane copolymers for their subsequent analysis by gel permeation chromatography (GPC).

Other Notes

复合物比相应的 β-环糊精复合物具有更高的水溶性；刺激脂肪酸的合成

General description

Heptakis(2,6-di-O-methyl)-β-cyclodextrin is a water-soluble derivative of cyclodextrin that exhibits the ability to effectively dissolve lipophilic drugs like steroid hormones, vitamins A, E, and K, etc. It can be used to improve the solubility and bioavailability of weakly hydrophilic pharmaceutical compounds.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCF6846
BCCF6041
BCCC7427
BCCB8810
BCBZ8457

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Effects of cyclodextrins on fatty acid synthesis.
Y Machida et al.
The Journal of biological chemistry, 248(17), 6246-6247 (1973-09-10)
Chiral separation of reduced haloperidol by capillary zone electrophoresis with heptakis (2, 6-di-O-methyl)-beta-cyclodextrin
Wu HL, et al.
Journal of Liquid Chromatography and Related Technologies, 19(10), 1567-1577 (1996)
New thermogelling copolymers composed of heptakis (2, 6-di-O-methyl)-beta-cyclodextrin, poly (propylene glycol), and poly (ethylene glycol)
Yang C, et al.
Journal of Materials Chemistry, 19(22), 3755-3763 (2009)
B. Casu et al.
Carbohydrate Research, 76, 59-59 (1979)
F Hirayama et al.
Journal of pharmaceutical sciences, 88(10), 970-975 (1999-10-09)
Acetyl groups were introduced to the hydroxyl groups of heptakis(2, 6-di-O-methyl)-beta-cyclodextrin (DM-beta-CyD), and the resulting heptakis(2,6-di-O-methyl-3-O-acetyl)-beta-CyD (DMA-beta-CyD) was evaluated for the inclusion property and hemolytic activity. It was confirmed by means of NMR and mass spectroscopies that in the DMA-beta-CyD
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