402184
6-氯-3-甲酰基-7-甲基色酮
98%
别名:
6-氯-7-甲基-4-氧-4H-1-苯并吡喃-3-甲醛
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关于此项目
经验公式（希尔记法）:
C11H7ClO3
化学文摘社编号:
分子量:
222.62
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
98%
产品名称
6-氯-3-甲酰基-7-甲基色酮, 98%
InChI
1S/C11H7ClO3/c1-6-2-10-8(3-9(6)12)11(14)7(4-13)5-15-10/h2-5H,1H3
SMILES string
Cc1cc2OC=C(C=O)C(=O)c2cc1Cl
InChI key
NULJNFUEBPQUNB-UHFFFAOYSA-N
assay
98%
mp
183-185 °C (lit.)
functional group
aldehyde
chloro
ketone
Gene Information
human ... PTPN1(5770)
Application
6-Chloro-3-formyl-7-methylchromone is the suitable reagent used in a study to investigate the multidrug resistabnce reversal by some 3- formylchromones in human colon cancer and mouse lymphoma cells transfected with the human MDR1 gene. It is the suitable reagent used in the synthesis of uridine-based library.
General description
6-Chloro-3-formyl-7-methylchromone (6-Chloro-7-methyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde) is a benzopyran derivative. It is a bicyclic heterocyclic molecule made up of a benzene ring fused to a heterocyclic pyran ring.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Zoltán Baráth et al.
In vivo (Athens, Greece), 20(5), 645-649 (2006-11-10)
Several new 3-formylchromone derivatives proved to be modifiers of multidrug resistance in mouse lymphoma cells and in human Colo320 colon cancer cells. There is apparently a structure-activity relationship between the antiproliferative multidrug resistance-reversing effect and the chemical structure of the
Howard C Hang et al.
Chemistry & biology, 11(3), 337-345 (2004-05-05)
The polypeptide N-acetyl-alpha-galactosaminyltransferases (ppGalNAcTs, also abbreviated ppGaNTases) initiate mucin-type O-linked glycosylation and therefore play pivotal roles in cell-cell communication and protection of tissues. In order to develop new tools for studying mucin-type O-linked glycosylation, we screened a 1338 member uridine-based
Juan Zhang et al.
The Analyst, 140(16), 5716-5723 (2015-07-15)
Inhibitors of protein tyrosine phosphatase 1B (PTP1B) are promising agents for the treatment of type 2 diabetes and obesity, so a colorimetric method has been developed in this work for PTP1B assay and screening of its inhibitors. The method is
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